从海洋来源真菌sp. HNMF114中分离得到的三种新的含喹唑啉吲哚生物碱。
Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus sp. HNMF114.
作者信息
Liu Sha-Sha, Yang Li, Kong Fan-Dong, Zhao Jia-Hui, Yao Li, Yuchi Zhi-Guang, Ma Qing-Yun, Xie Qing-Yi, Zhou Li-Man, Guo Meng-Fei, Dai Hao-Fu, Zhao You-Xing, Luo Du-Qiang
机构信息
College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, China.
出版信息
Front Microbiol. 2021 Jun 2;12:680879. doi: 10.3389/fmicb.2021.680879. eCollection 2021.
By feeding tryptophan to the marine-derived fungus sp. HNMF114 from the bivalve mollusk , 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (-), along with 16 known ones (-), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra. Structurally, compound represents the first example of this type of compound, bearing an amide group at C-3. Compounds and showed potent α-glucosidase inhibitory activity with IC values of 7.18 and 5.29 μM, and compounds and showed a clear activation effect on the ryanodine receptor from (sfRyR), which reduced the [Ca] by 37.1 and 36.2%, respectively.
通过向源自双壳贝类软体动物的海洋真菌sp. HNMF114投喂色氨酸，获得了3种新的含喹唑啉的吲哚生物碱，命名为aspertoryadins H-J (-)，以及16种已知的生物碱(-)。通过光谱数据分析结合核磁共振（NMR）化学位移和电子捕获检测器（ECD）光谱的量子化学计算，阐明了新化合物的结构。在结构上，化合物代表了这类化合物的首个实例，在C-3位带有一个酰胺基团。化合物 和 表现出较强的α-葡萄糖苷酶抑制活性，IC值分别为7.18和5.29 μM，化合物 和 对来自 （sfRyR）的兰尼碱受体表现出明显的激活作用，分别使[Ca] 降低了37.1%和36.2%。
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