Dima Augustin Catalin, Balaban Daniel Vasile, Dima Alina
Department of General Surgery and Department of Gastroenterology, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Diagnostics (Basel). 2021 Dec 9;11(12):2317. doi: 10.3390/diagnostics11122317.
Volatile organic compounds (VOCs) are part of the exhaled breath that were proposed as non-invasive breath biomarkers via different human discharge products like saliva, breath, urine, blood, or tissues. Particularly, due to the non-invasive approach, VOCs were considered as potential biomarkers for non-invasive early cancer detection. We herein aimed to review the data over VOCs utility in digestive neoplasia as early diagnosis or monitoring biomarkers. A systematic literature search was done using MEDLINE via PubMed, Cochrane Library, and Thomson Reuters' Web of Science Core Collection. We identified sixteen articles that were included in the final analysis. Based on the current knowledge, we cannot identify a single VOC as a specific non-invasive biomarker for digestive neoplasia. Several combinations of up to twelve VOCs seem promising for accurately detecting some neoplasia types. A combination of different VOCs breath expression are promising tools for digestive neoplasia screening.
挥发性有机化合物（VOCs）是呼出气体的一部分，通过唾液、呼吸、尿液、血液或组织等不同人体排出物被提议作为非侵入性呼吸生物标志物。特别是，由于采用非侵入性方法，VOCs被视为非侵入性早期癌症检测的潜在生物标志物。我们在此旨在综述有关VOCs在消化系肿瘤中作为早期诊断或监测生物标志物的应用数据。通过PubMed、Cochrane图书馆和汤森路透的Web of Science核心合集使用MEDLINE进行了系统的文献检索。我们确定了16篇文章纳入最终分析。基于目前的知识，我们无法确定单一的VOC作为消化系肿瘤的特异性非侵入性生物标志物。多达12种VOCs的几种组合似乎有望准确检测某些肿瘤类型。不同VOCs呼吸表达的组合是消化系肿瘤筛查的有前景的工具。
