Pastorek Dusan, Culenova Martina, Csobonyeiova Maria, Skuciova Veronika, Danisovic Lubos, Ziaran Stanislav
Department of Urology, University Hospital Bratislava, Pazitkova 4, 821 01 Bratislava, Slovakia.
Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.
Biomedicines. 2021 Dec 15;9(12):1917. doi: 10.3390/biomedicines9121917.
Tissue engineering (TE) is a promising approach for repair/substitution of damaged tissues and organs. Urethral strictures are common and serious health conditions that impair quality of life and may lead to serious organ damage. The search for ideal materials for urethral repair has led to interest of scientists and surgeons in urethral TE. Over the last decades, a significant amount of preclinical studies and considerable progress have been observed. In contrast, urethral TE has made slow progress in clinical practice so far. To address this, we conducted a systematic review of the literature on clinical applications of TE constructs for urethral repair in the last three decades. In summary, the TE approach is promising and effective, but many issues remain that need to be addressed for broader adoption of TE in urethral repair. Better design of trials, better cooperation of research groups and centralization could lead to reduction of costs and slowly proceed to commercialization and routine use of TE products for urethral reconstruction.
组织工程（TE）是一种用于修复/替代受损组织和器官的有前景的方法。尿道狭窄是常见且严重的健康问题，会损害生活质量并可能导致严重的器官损伤。对理想尿道修复材料的探索引发了科学家和外科医生对尿道组织工程的兴趣。在过去几十年中，已观察到大量的临床前研究及显著进展。相比之下，迄今为止尿道组织工程在临床实践中的进展缓慢。为解决这一问题，我们对过去三十年中组织工程构建体用于尿道修复的临床应用文献进行了系统综述。总之，组织工程方法前景广阔且有效，但仍有许多问题需要解决，以便在尿道修复中更广泛地采用组织工程。更好的试验设计、研究团队之间更好的合作以及集中化可能会降低成本，并逐步实现组织工程产品用于尿道重建的商业化和常规使用。
