Hu Meiyi, Zhang Li, Ruan Zheng, Han Peiheng, Yu Yujuan
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.
State Key Laboratory of Food Science and Technology, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
Foods. 2021 Dec 6;10(12):3022. doi: 10.3390/foods10123022.
navel orange and pomelo, belonging to the genus Citrus, are good sources of phenolic compounds, which are mainly concentrated in the peel. These phenolic compounds are considered promising in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). In order to maximize nutrients retention and bioactivity in the peel, pomelo peel and orange peel were processed using freeze-drying technology and mixed in the ratio (pomelo peel powder 50% and orange peel powder 50%) to make citrus peel powder (CPP). The purpose of this study was to explore new strategies and mechanisms associated with the consumption of CPP to alleviate nonalcoholic fatty liver injury, lipid metabolism disorders, and gut microbiota dysbiosis in obese mice induced by high-fat diet (HFD). The results showed that after 12 weeks of CPP administration, CPP supplementation had a strong inhibitory effect on HFD-induced weight gain, hepatic fat accumulation, dyslipidemia, and the release of pro-inflammatory cytokines. In particular, CPP modulates the composition of the intestinal flora, such as increasing the relative abundance of phylum , genus , genus , genus , and genus and decreasing the relative abundance of phylum , genus , and genus . These results suggest that CPP has a preventive effect on NAFLD, which can be related to the regulation of intestinal flora.
脐橙和柚子属于柑橘属，是酚类化合物的良好来源，这些酚类化合物主要集中在果皮中。这些酚类化合物在非酒精性脂肪性肝病（NAFLD）的预防和治疗方面被认为很有前景。为了最大程度地保留果皮中的营养成分和生物活性，采用冷冻干燥技术对柚皮和橙皮进行处理，并按比例（柚皮粉50%和橙皮粉50%）混合制成柑橘皮粉（CPP）。本研究的目的是探索与食用CPP相关的新策略和机制，以减轻高脂饮食（HFD）诱导的肥胖小鼠的非酒精性脂肪性肝损伤、脂质代谢紊乱和肠道微生物群失调。结果表明，给予CPP 12周后，补充CPP对HFD诱导的体重增加、肝脏脂肪堆积、血脂异常和促炎细胞因子的释放具有强烈的抑制作用。特别是，CPP调节肠道菌群的组成，例如增加门 、属 、属 、属 和属 的相对丰度，并降低门 、属 和属 的相对丰度。这些结果表明，CPP对NAFLD具有预防作用，这可能与肠道菌群的调节有关。
