Moon Hyun, Sim Changsun, Lee Jiho, Oh Inbo, An Taehoon, Lee Jongcheol
Department of Otorhinolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea.
Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea.
J Pers Med. 2021 Dec 3;11(12):1290. doi: 10.3390/jpm11121290.
Oxidative stress has been known to play an important role in inflammatory responses of allergic rhinitis. We investigated the association between degree of oxidative stress and severity of allergic rhinitis. A total 226 allergic rhinitis students were classified by a history of allergic rhinitis into groups according to number and duration of symptoms within the previous year. The total antioxidant status (TAS) and total oxidant status (TOS) levels were compared among groups. Mean TAS level (14.03 ± 9.09 mmol/L) in the group with more than six months of symptoms had a tendency to be higher ( = 0.068) than that of the group with fewer than six months (12.33 ± 8.83 mmol/L). There was no statistically significant difference in mean TAS or TOS level with number of symptoms (nasal congestion, itching, sneezing and watery rhinorrhea). A multivariate logistic regression showed that the adjusted odds ratio of TAS was 1.655 and the adjusted odds ratio of TOS was 0.972 in more than a six-month duration group. The TAS level was significantly associated with a more than six-month symptom duration ( = 0.034). Our results suggest that antioxidant activity increased when allergic rhinitis became chronic and further research will be needed considering the disease severity.
氧化应激在过敏性鼻炎的炎症反应中起着重要作用。我们研究了氧化应激程度与过敏性鼻炎严重程度之间的关联。根据过敏性鼻炎病史，将总共226名患过敏性鼻炎的学生按照前一年症状的数量和持续时间分为不同组。比较了各组的总抗氧化状态（TAS）和总氧化状态（TOS）水平。症状持续超过六个月的组的平均TAS水平（14.03±9.09毫摩尔/升）有高于症状持续少于六个月的组（12.33±8.83毫摩尔/升）的趋势（P = 0.068）。平均TAS或TOS水平与症状数量（鼻塞、瘙痒、打喷嚏和水样鼻漏）之间无统计学显著差异。多因素逻辑回归显示，在症状持续超过六个月的组中，TAS的调整优势比为1.655，TOS的调整优势比为0.972。TAS水平与症状持续超过六个月显著相关（P = 0.034）。我们的结果表明，当过敏性鼻炎变为慢性时抗氧化活性增加，考虑到疾病严重程度还需要进一步研究。
