Berta Lavinia, Coman Năstaca-Alina, Rusu Aura, Tanase Corneliu
Department of General and Inorganic Chemistry, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, 540139 Târgu Mureș, Romania.
Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.
Materials (Basel). 2021 Dec 13;14(24):7677. doi: 10.3390/ma14247677.
The study of bimetallic nanoparticles (BNPs) has constantly been expanding, especially in the last decade. The biosynthesis of BNPs mediated by natural extracts is simple, low-cost, and safe for the environment. Plant extracts contain phenolic compounds that act as reducing agents (flavonoids, terpenoids, tannins, and alkaloids) and stabilising ligands moieties (carbonyl, carboxyl, and amine groups), useful in the green synthesis of nanoparticles (NPs), and are free of toxic by-products. Noble bimetallic NPs (containing silver, gold, platinum, and palladium) have potential for biomedical applications due to their safety, stability in the biological environment, and low toxicity. They substantially impact human health (applications in medicine and pharmacy) due to the proven biological effects (catalytic, antioxidant, antibacterial, antidiabetic, antitumor, hepatoprotective, and regenerative activity). To the best of our knowledge, there are no review papers in the literature on the synthesis and characterisation of plant-mediated BNPs and their pharmacological potential. Thus, an effort has been made to provide a clear perspective on the synthesis of BNPs and the antioxidant, antibacterial, anticancer, antidiabetic, and size/shape-dependent applications of BNPs. Furthermore, we discussed the factors that influence BNPs biosyntheses such as pH, temperature, time, metal ion concentration, and plant extract.
双金属纳米颗粒（BNPs）的研究一直在不断扩展，尤其是在过去十年中。由天然提取物介导的BNPs生物合成简单、低成本且对环境安全。植物提取物含有酚类化合物，这些化合物可作为还原剂（黄酮类、萜类、单宁和生物碱）以及稳定配体部分（羰基、羧基和胺基），有助于纳米颗粒（NPs）的绿色合成，并且没有有毒副产物。贵金属双金属纳米颗粒（包含银、金、铂和钯）因其安全性、在生物环境中的稳定性和低毒性而具有生物医学应用潜力。由于已证实的生物学效应（催化、抗氧化、抗菌、抗糖尿病、抗肿瘤、肝脏保护和再生活性），它们对人类健康有重大影响（在医学和药学中的应用）。据我们所知，文献中没有关于植物介导的BNPs的合成与表征及其药理潜力的综述文章。因此，我们努力就BNPs的合成以及BNPs的抗氧化、抗菌、抗癌、抗糖尿病和尺寸/形状依赖性应用提供清晰的观点。此外，我们还讨论了影响BNPs生物合成的因素，如pH值、温度、时间、金属离子浓度和植物提取物。
