维甲酸受体的天然配体 ATRA 在乳腺癌 EMT 相关蛋白中的作用：综述。

Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czech Republic.

Institute of Analytical Chemistry of the CAS, v. v. i., 602 00 Brno, Czech Republic.

Int J Mol Sci. 2021 Dec 12;22(24):13345. doi: 10.3390/ijms222413345.

The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all- retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.

了解 EMT 过程中特定蛋白质的结构、功能和丰度对于开发有效的癌症诊断方法至关重要，这有助于癌症的诊断和治疗。全反式维甲酸 (ATRA) 分化疗法在急性早幼粒细胞白血病中的成功应用刺激了用 ATRA 治疗其他肿瘤的研究。本综述将讨论 ATRA 应用的影响，强调 EMT 蛋白在乳腺癌中的作用，其中转移和复发是导致死亡的主要原因。