Biswas Subhrajyoti, Ghosh Ritwik, Mandal Arpan, Pandit Alak, Roy Dipayan, Sengupta Samya, De Kaustav, Swaika Bikash Chandra, Benito-León Julián
Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India.
Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, India.
Neurohospitalist. 2022 Jan;12(1):111-116. doi: 10.1177/19418744211016709. Epub 2021 May 17.
A plethora of neurological manifestations are associated with the 2019 coronavirus infectious disease (COVID-19). We hereby report the first case of a patient infected with SARS-CoV-2 who acutely presented with autonomic dysfunction preceding the onset of complete clinical picture of Miller Fisher syndrome. She was finally diagnosed to be a case of anti-ganglioside antibody positive post-COVID-19 Miller Fisher syndrome with dysautonomia and treated with intravenous immunoglobulin with an excellent response. We also discuss the plausible pathogenic mechanisms of COVID-19 induced Miller Fisher syndrome and furnish a review of the post-COVID-19 Miller Fisher syndrome cases reported.
大量神经系统表现与2019冠状病毒感染疾病（COVID-19）相关。我们在此报告首例感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的患者，该患者在出现米勒-费希尔综合征（Miller Fisher syndrome）完整临床表现之前急性出现自主神经功能障碍。她最终被诊断为COVID-19后抗神经节苷脂抗体阳性的米勒-费希尔综合征伴自主神经功能障碍，并接受静脉注射免疫球蛋白治疗，反应良好。我们还讨论了COVID-19诱发米勒-费希尔综合征可能的致病机制，并对已报道的COVID-19后米勒-费希尔综合征病例进行了综述。
