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新冠疫情时代的米勒-费雪综合征——一种新型靶抗原呼唤新型治疗方法

Miller Fisher Syndrome in the COVID-19 Era - A Novel Target Antigen Calls for Novel Treatment.

作者信息

Kajani Surina, Kajani Raheem, Huang Chin-Wei, Tran Tu, Liu Antonio K

机构信息

Medicine, Adventist Health White Memorial, Los Angeles, USA.

Critical Care, Los Angeles Community Hospital, Los Angeles, USA.

出版信息

Cureus. 2021 Jan 1;13(1):e12424. doi: 10.7759/cureus.12424.

Abstract

Although Miller Fisher syndrome cases have been published in this coronavirus disease 2019 (COVID-19) pandemic, anti-GQ1b antibody has not been identified so far. A direct proof of association is not yet available since the exact pathophysiology is not known. Using a proof of contradiction argument, lack of GQ1b serves as the indirect proof that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is probably the infection preceding demyelination. A novel antigen has yet to be described.

摘要

尽管在2019冠状病毒病(COVID-19)大流行期间已有米勒-费希尔综合征病例的报道,但迄今为止尚未发现抗GQ1b抗体。由于确切的病理生理学尚不清楚,因此尚未有直接的关联证据。通过反证法,缺乏GQ1b可作为间接证据,表明严重急性呼吸综合征冠状病毒2(SARS-CoV-2)可能是脱髓鞘之前的感染源。一种新的抗原尚未被描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc98/7779142/681df657b6c6/cureus-0013-00000012424-i01.jpg

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