Köksal Muammer Osman, Yalçın Başak Keskin, Keskin Fahriye, Çiftçi Sevgi, Yağcı Ibrahim, Hasçiçek Seyhan Özakkoyunlu, Başaran Bora, Değer Kemal, Ağaçfidan Ali, Quaas Alexander, Akgül Baki
Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, 34116 Istanbul, Turkey.
Pathogens. 2021 Nov 23;10(12):1533. doi: 10.3390/pathogens10121533.
Human papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in oral and oropharyngeal cancers. To investigate the frequency of HPV-driven HNSCC among patients living in Turkey, HPV DNA positivity and p16INK4A expression were assessed in primary tumor biopsies (n = 106). Eighteen out of one hundred and six (19%) HNSCC tumors showed p16INK4A overexpression, and 26/106 cases (24.5%) were positive for HPV DNA. Sixteen out of twenty-six samples were positive for both HPV DNA and p16INK4A staining. HPV16 could be isolated from 22/26 samples (84.6%) and was found to be the most frequently detected HPV type. This study represents the largest cohort of Turkish patients with HNSCC characterized according to HPV status and p16INK4A expression. Our data suggest that HPV16 infection, along with smoking, contribute to the development of HNSCC.
在发达国家，人乳头瘤病毒（HPV）相关肿瘤在头颈部鳞状细胞癌（HNSCC）中占相当大的比例。近年来，与HNSCC相关的HPV感染有所增加，尤其是HPV16，它是在口腔癌和口咽癌中最常检测到的类型。为了调查生活在土耳其的患者中HPV驱动的HNSCC的发生率，对原发性肿瘤活检样本（n = 106）进行了HPV DNA阳性和p16INK4A表达评估。106例HNSCC肿瘤中有18例（19%）显示p16INK4A过表达，26/106例（24.5%）HPV DNA呈阳性。26个样本中有16个HPV DNA和p16INK4A染色均为阳性。22/26个样本（84.6%）可分离出HPV16，且发现它是最常检测到的HPV类型。本研究代表了根据HPV状态和p16INK4A表达进行特征描述的最大规模土耳其HNSCC患者队列。我们的数据表明，HPV16感染与吸烟一起，促成了HNSCC的发生。
