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SAU-19 改善高脂肪饮食/链脲佐菌素诱导的糖尿病小鼠的肝胰岛素抵抗。

SAU-19 Ameliorates Hepatic Insulin Resistance in High-Fat Diet/Streptozocin-Induced Diabetic Mice.

机构信息

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

New Ruipeng Pet Healthcare Group Co., Ltd., Shenzhen 518000, China.

出版信息

Nutrients. 2021 Dec 17;13(12):4512. doi: 10.3390/nu13124512.

DOI:10.3390/nu13124512
PMID:34960064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8703646/
Abstract

Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This study was performed to investigate the antidiabetic effect of SAU-19 and its possible mechanisms of action in mice with type 2 diabetes mellitus (T2DM). Thirty SPFKM mice were randomly assigned to three groups: control, diabetic model, and diabetes + SAU-19 group. After 35 days, blood was collected for biochemical analysis and liver tissue samples for histopathological analysis using H&E staining, qPCR, and ELISA. The results showed that the administration of SAU-19 significantly improved the blood glucose, hepatic insulin resistance, and morphological changes of the liver characterized by significant improvement of dyslipidemia, glycogen synthesis, and antioxidant status ( < 0.05), indicating the strains' ameliorating effects on hepatic insulin resistance in T2DM. In conclusion, the probiotic strain SAU-19) inhibits T2DM by reducing insulin resistance, improving antioxidant status, and downregulating genes related to glucose synthesis; hence, it may be used in treating diabetes and other metabolic disorders. This study provides the basis for further studies into the molecular mechanisms of SAU-19 in treating T2DM.

摘要

胰岛素抵抗（IR）是 2 型糖尿病（T2DM）的标志。本研究旨在探讨 SAU-19 在 2 型糖尿病（T2DM）小鼠中的降糖作用及其可能的作用机制。30 只 SPFKM 小鼠被随机分为三组：对照组、糖尿病模型组和糖尿病+SAU-19 组。35 天后，采集血液进行生化分析，采集肝组织样本进行 H&E 染色、qPCR 和 ELISA 分析。结果表明，SAU-19 的给药显著改善了血糖、肝胰岛素抵抗和肝脏形态学变化，表现为血脂异常、糖原合成和抗氧化状态的显著改善（<0.05），表明该菌株对 T2DM 肝胰岛素抵抗具有改善作用。总之，益生菌株 SAU-19 通过降低胰岛素抵抗、改善抗氧化状态和下调与葡萄糖合成相关的基因来抑制 T2DM，因此，它可能用于治疗糖尿病和其他代谢紊乱。本研究为进一步研究 SAU-19 治疗 T2DM 的分子机制提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29ab/8703646/f44615e6a4a8/nutrients-13-04512-g009.jpg
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