Mirmiranpour Hossein, Huseini Hasan Fallah, Derakhshanian Hoda, Khodaii Zohreh, Tavakoli-Far Bahareh
Endocrinology and Metabolism Research Center (EMRC) Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
J Diabetes Metab Disord. 2019 Dec 23;19(1):53-60. doi: 10.1007/s40200-019-00474-3. eCollection 2020 Jun.
The aim of this study was to investigate the effect of probiotic bacteria of , cinnamon powder and their combinations on the glycemic and antioxidant indices in patients with type 2 diabetes.
A total of 136 patients randomized with type 2 diabetes entered the study and were randomly divided into four groups who were matched for age and gender. Thereafter, alongside their routine pharmacotherapy, each group followed one of the following diets: Group A: 10 cfu and 0.5 g of powdered cinnamon (synbiotic). Group B: (probiotic), Group C: powdered cinnamon. Group D: rice flour powder as placebo. At the beginning and end of the intervention, fasting blood sugar (FBS), HbA1c, advance glycation end products (AGE), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and antioxidant enzymes of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured.
Following 3 months of treatment, the mean FBS level was decreased significantly in probiotic, cinnamon, and synbiotic supplementation groups compared with control ( < 0.01). FBS levels in probiotic, cinnamon, and synbiotic groups were significantly decreased compared with the control group ( = 0.001, = 0.063 and = 0.001, respectively). The mean HbA1C in probiotic, cinnamon, and synbiotic groups were also decreased ( 0.001, = 0.001 and = 0.04, respectively). The mean AGE in synbiotic group was significantly decreased ( = 0.037). Probiotic, cinnamon and synbiotic all could improve antioxidant enzyme activity modestly. However, the most significant effect was seen in probiotic group.
According to the current results, the use of probiotic supplements (individually or in combination with cinnamon) leads to a reduction in blood glucose and an increase in antioxidant enzymes in people with type 2 diabetes.
本研究旨在探讨益生菌、肉桂粉及其组合对2型糖尿病患者血糖和抗氧化指标的影响。
共有136例2型糖尿病患者随机进入本研究，并按年龄和性别随机分为四组。此后，在常规药物治疗的基础上，每组遵循以下饮食之一：A组：10 cfu益生菌和0.5 g肉桂粉（合生元）。B组：益生菌。C组：肉桂粉。D组：米粉作为安慰剂。在干预开始和结束时，测量空腹血糖（FBS）、糖化血红蛋白（HbA1c）、晚期糖基化终末产物（AGE）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）以及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）等抗氧化酶。
治疗3个月后，益生菌、肉桂和合生元补充组的平均FBS水平与对照组相比显著降低（P<0.01）。益生菌、肉桂和合生元组的FBS水平与对照组相比显著降低（P分别为0.001、0.063和0.001）。益生菌、肉桂和合生元组的平均HbA1C也降低（P分别为0.001、0.001和0.04）。合生元组的平均AGE显著降低（P=0.037）。益生菌、肉桂和合生元均可适度提高抗氧化酶活性。然而，益生菌组的效果最为显著。
根据目前的结果，使用益生菌补充剂（单独或与肉桂联合使用）可降低2型糖尿病患者的血糖并提高抗氧化酶水平。
