Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Dermatology, Hofstra/Northwell Donald and Barbara Zucker School of Medicine, New Hyde Park, New York, USA.
J Cutan Pathol. 2022 May;49(5):491-495. doi: 10.1111/cup.14192. Epub 2022 Jan 19.
Cutaneous collagenous vasculopathy is a rare pauci-inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine-branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti-endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti-ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune- and non-immune-based endothelial cell injury in the pathogenesis of collagenous vasculopathy.
皮肤胶原性血管病是一种罕见的少炎、浅表性皮肤血管病，临床上表现为进行性细分支状毛细血管扩张，而在光镜下观察到真皮浅层扩张的小静脉和毛细血管，血管壁内有过多的 IV 型胶原。我们报告三例胶原性血管病。两例与某些自身免疫标志有关，包括一例血清抗内皮细胞抗体检测阳性和狼疮抗凝物阳性，而第三例则有抗核糖核蛋白（RNP）抗体阳性。后者与慢性羟基脲治疗潜在的骨髓增生性疾病有关。我们探讨了免疫和非免疫性内皮细胞损伤在胶原性血管病发病机制中的作用。
