Bondier Laure, Tardieu Mathilde, Leveque Perrine, Challende Isabelle, Pinel Nicole, Leccia Marie T
*Department of Dermatology, Grenoble University Hospital, Grenoble, France; †Joseph Fournier University, Grenoble, France; and ‡Department of Skin Pathology, Grenoble University Hospital, Grenoble, France.
Am J Dermatopathol. 2017 Sep;39(9):682-688. doi: 10.1097/DAD.0000000000000613.
Cutaneous collagenous vasculopathy is a recently described idiopathic microangiopathy characterized by acquired diffuse cutaneous telangiectasias and specific histological features: dilated capillaries in the superficial dermis, with walls thickened by hyaline material containing collagen IV by immunohistochemistry. The authors describe 2 cases and review all cases reported in the literature to date, 34 cases including our own. Cases were mainly observed in women (sex ratio 0.41), median age 63.5 (16-85). Hypertension and diabetes seem more frequent in these patients than in the general population. Typical clinical presentation is fine hair telangiectasias appearing on the lower limbs and progressing toward the trunk and upper limbs, sparing the face. Facial and neck involvement are however reported. When faced with isolated acquired diffuse cutaneous telangiectasias, clinicians should perform a skin biopsy to rule out cutaneous collagenous vasculopathy.
皮肤胶原性血管病是一种最近描述的特发性微血管病，其特征为获得性弥漫性皮肤毛细血管扩张及特定组织学特征：真皮浅层毛细血管扩张，免疫组化显示血管壁因含IV型胶原的透明物质而增厚。作者描述了2例病例，并回顾了迄今为止文献报道的所有病例，包括我们自己的病例在内共34例。病例主要见于女性（性别比0.41），中位年龄63.5岁（16 - 85岁）。这些患者中高血压和糖尿病的发生率似乎高于一般人群。典型的临床表现是下肢出现纤细的毛发状毛细血管扩张，并向躯干和上肢发展，不累及面部。然而，也有面部和颈部受累的报道。当面对孤立的获得性弥漫性皮肤毛细血管扩张时，临床医生应进行皮肤活检以排除皮肤胶原性血管病。
