Hellen E A, Rowlands D C, Hansel T T, Kitas G D, Crocker J
Department of Histopathology, East Birmingham Hospital.
J Clin Pathol. 1991 Apr;44(4):293-6. doi: 10.1136/jcp.44.4.293.
The leucocyte antigen CD23 is expressed by B lymphocytes following activation by a number of stimuli and functions as an IgE receptor, and in its soluble form, as a putative B cell growth factor. The expression of CD23 on the surface of lymphocytes in paraffin wax sections of synovial biopsy specimens was studied using a novel mouse monoclonal antibody, BU38. Specimens were investigated from nine cases of rheumatoid arthritis, six cases of osteoarthritis, and eight cases of chronic inflammation in articular and non-articular tissues. CD23 was expressed on a high proportion of lymphocytes in all forms of chronic inflammation and was not specific for rheumatoid arthritis. It may be a characteristic feature of any chronic inflammatory response. As CD23 was found on the surface of lymphocytes in many cases of these arthritides, sCD23 in serum or synovial fluid may yet prove a useful marker for the severity of the inflammatory infiltrate.
白细胞抗原CD23在多种刺激激活B淋巴细胞后表达，作为一种IgE受体发挥作用，其可溶性形式则作为一种假定的B细胞生长因子。使用新型小鼠单克隆抗体BU38研究了滑膜活检标本石蜡切片中淋巴细胞表面CD23的表达。对9例类风湿性关节炎、6例骨关节炎以及8例关节和非关节组织慢性炎症的标本进行了研究。在所有形式的慢性炎症中，高比例的淋巴细胞表达CD23，且并非类风湿性关节炎所特有。它可能是任何慢性炎症反应的一个特征。由于在这些关节炎的许多病例中淋巴细胞表面都发现了CD23，血清或滑液中的可溶性CD23（sCD23）可能会被证明是炎症浸润严重程度的一个有用标志物。
