人皮肤在体内释放白细胞介素-1样活性物质。
Release in vivo of IL-1 like activity by human skin.
作者信息
Dowd P M, Hudspith B N, Miller J A, Barr R M, Brostoff J, Greaves M W
出版信息
Clin Exp Immunol. 1987 Mar;67(3):606-10.
We have demonstrated the release in vivo by normal human skin of a factor which possesses IL-1-like activity in the mouse thymocyte amplification assay. Quantitatively similar amounts of this factor were released from involved and uninvolved skin of patients with cutaneous T cell lymphoma. The IL-1-like factor was associated with inhibitory activity in the mouse thymocyte amplification assay. High performance liquid chromatographic analysis showed that this inhibitory activity co-chromatographed with prostaglandin E2. These results provide further evidence for the role of the skin as an immunologically active organ and suggest that PGE2 may have an immunomodulatory role in human skin.
我们已经证明，在小鼠胸腺细胞增殖试验中，正常人皮肤可在体内释放一种具有白细胞介素-1样活性的因子。皮肤T细胞淋巴瘤患者的受累皮肤和未受累皮肤释放的这种因子数量在定量上相似。在小鼠胸腺细胞增殖试验中，这种白细胞介素-1样因子具有抑制活性。高效液相色谱分析表明，这种抑制活性与前列腺素E2共色谱。这些结果为皮肤作为免疫活性器官的作用提供了进一步证据，并表明前列腺素E2可能在人类皮肤中具有免疫调节作用。
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