Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil.
Curr Top Microbiol Immunol. 2021;432:19-33. doi: 10.1007/978-3-030-83391-6_3.
Species of the Paracoccidioides brasiliensis complex and P. lutzii cause human paracoccidioidomycosis (PCM). Early interest in Paracoccidioides extracellular vesicles (EVs) resulted in a series of publications that unraveled the EVs protein, carbohydrate, lipid, and RNA cargo from isolates of different phylogenetic groups and distinct virulence degrees. EV and cell wall components were compared. These works are discussed in parallel with more recent data on the role of Paracoccidioides EVs in immunomodulation.
巴西副球孢子菌和卢氏副球孢子菌复合体的种属可引起人类副球孢子菌病（PCM）。人们对副球孢子菌细胞外囊泡（EVs）早期的兴趣产生了一系列的出版物，这些出版物揭示了不同系统发育群和不同毒力程度的分离株中 EVs 的蛋白、碳水化合物、脂质和 RNA 货物。比较了 EV 和细胞壁成分。这些工作与关于副球孢子菌 EVs 在免疫调节中的作用的最新数据进行了平行讨论。
