乳腺癌正电子发射断层磁共振成像的临床进展。
Clinical advances in PET-MRI for breast cancer.
机构信息
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
出版信息
Lancet Oncol. 2022 Jan;23(1):e32-e43. doi: 10.1016/S1470-2045(21)00577-5.
Abstract
Imaging is paramount for the early detection and clinical staging of breast cancer, as well as to inform management decisions and direct therapy. PET-MRI is a quantitative hybrid imaging technology that combines metabolic and functional PET data with anatomical detail and functional perfusion information from MRI. The clinical applicability of PET-MRI for breast cancer is an active area of research. In this Review, we discuss the rationale and summarise the clinical evidence for the use of PET-MRI in the diagnosis, staging, prognosis, tumour phenotyping, and assessment of treatment response in breast cancer. The continued development and approval of targeted radiopharmaceuticals, together with radiomics and automated analysis tools, will further expand the opportunity for PET-MRI to provide added value for breast cancer imaging and patient care.
摘要
成像对于乳腺癌的早期检测和临床分期至关重要，有助于做出管理决策并指导治疗。PET-MRI 是一种定量的混合成像技术，它将代谢和功能 PET 数据与 MRI 的解剖细节和功能灌注信息相结合。PET-MRI 在乳腺癌中的临床应用是一个活跃的研究领域。在这篇综述中，我们讨论了在乳腺癌的诊断、分期、预后、肿瘤表型以及治疗反应评估中使用 PET-MRI 的基本原理和临床证据。随着靶向放射性药物的不断发展和批准，以及放射组学和自动分析工具的应用，PET-MRI 将有更多机会为乳腺癌成像和患者护理提供附加价值。
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