Verschoor M, Herber R, van Hemmen J, Wibowo A, Zielhuis R
Scand J Work Environ Health. 1987 Jun;13(3):232-8. doi: 10.5271/sjweh.2065.
The influence of occupational exposure to cadmium on renal function was examined in 27 male cadmium workers from plants with second-degree usage of cadmium. The levels of cadmium in the blood and urine and various protein concentrations in the urine and serum were determined. The urinary levels of beta 2-microglobulin, retinol-binding protein, and N-acetyl-beta-D-glucosaminidase were statistically significantly increased in workers with urinary cadmium levels above 50 nmol/l. SDS-PAGE electrophoresis with silver staining is probably a sensitive indicator of the early effects of cadmium on protein excretion. The currently recommended biological exposure limits may have to be lowered.
对来自镉二级使用工厂的27名男性镉作业工人，研究了职业性接触镉对肾功能的影响。测定了血液和尿液中的镉水平以及尿液和血清中各种蛋白质的浓度。尿镉水平高于50 nmol/l的工人，其尿液中β2-微球蛋白、视黄醇结合蛋白和N-乙酰-β-D-氨基葡萄糖苷酶水平在统计学上显著升高。采用银染色的SDS-PAGE电泳可能是镉对蛋白质排泄早期影响的敏感指标。目前推荐的生物接触限值可能需要降低。
