Yarizadeh Habib, Hassani Bahar, Nosratabadi Saeed, Baharlooi Hussein, Asadi Sara, Bagherian Seyed Ahmad, Islam Shariful, Djafarian Kurosh, Mirzaei Khadijeh
Students' Scientific Center, Tehran University of Medical Sciences (TUMS), P.O. Box 1417755331, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Evid Based Complement Alternat Med. 2021 Dec 22;2021:6213035. doi: 10.1155/2021/6213035. eCollection 2021.
It is uncertain if omega-3 polyunsaturated fatty acids are associated with increase in resting metabolic rate (RMR) in adults.
The aim of the present study was to evaluate the overall effects of omega-3 on RMR.
Both PubMed and Scopus libraries were searched up to April 2021. Study quality was assessed using the Jadad scale. Random- and fixed-effects models were utilized in order to obtain pooled estimates of omega-3 supplementation impacts on RMR, using weight mean difference (WMD).
Seven studies including a total of 245 participants were included. There was significantly higher FFM-adjusted RMR in the intervention group than the control group (WMD: 26.666 kcal/kg/day, 95% CI: 9.010 to 44.322, =0.003). Study quality showed that four of seven included studies were of high quality. However, there was no significant difference in results in the subgroup analysis according to the quality of studies. Subgroup analyses revealed significant changes for sex (for women: WMD = 151.793 kcal/day, 95% CI = 62.249 to 241.337, =0.001) and BMI (for BMI > 25: WMD = 82.208 kcal/day, 95% CI = 0.937 to 163.480, =0.047). Influence analysis indicated no outlier among inclusions.
The current study depicted that omega-3 polyunsaturated acids can significantly increase RMR in adults. However, further assessments of omega-3 supplementation therapy are critical to monitor its long-term outcomes and potential clinical application.
目前尚不确定ω-3多不饱和脂肪酸是否与成年人静息代谢率（RMR）的增加有关。
本研究旨在评估ω-3对RMR的总体影响。
检索了截至2021年4月的PubMed和Scopus数据库。使用Jadad量表评估研究质量。采用随机效应模型和固定效应模型，以体重平均差（WMD）获得ω-3补充剂对RMR影响的合并估计值。
纳入了7项研究，共245名参与者。干预组经去脂体重调整后的RMR显著高于对照组（WMD：26.666千卡/千克/天，95%CI：9.010至44.322，P=0.003）。研究质量显示，7项纳入研究中有4项为高质量研究。然而，根据研究质量进行的亚组分析结果无显著差异。亚组分析显示，性别（女性：WMD = 151.793千卡/天，95%CI = 62.249至241.337，P = 0.001）和BMI（BMI>25：WMD = 82.208千卡/天，95%CI = 0.937至163.480，P = 0.047）有显著变化。影响分析表明纳入研究中无异常值。
本研究表明，ω-3多不饱和脂肪酸可显著提高成年人的RMR。然而，进一步评估ω-3补充疗法对于监测其长期效果和潜在临床应用至关重要。
