Gu Xin, Shi Xiaofen, Zhang Limin, Zhou Ying, Cai Yinghua, Jiang Wujia, Zhou Qunyan
Department of Obstetrics, Wuxi People's Hospital, Wuxi, China.
Department of Nursing, Wuxi People's Hospital, Wuxi, China.
Transl Pediatr. 2021 Nov;10(11):3058-3067. doi: 10.21037/tp-21-476.
To search for and collect evidence on human milk fortifier in preterm infants, and to summarize the latest and best evidence, so as to provide reference for clinical work.
We searched the databases of UpToDate, American Guide Network, Cochrane Library, Joanna Briggs Institute (JBI), PubMed, ResearchGate, China National Knowledge Infrastructure (CNKI), Wan Fang, Chinese Biology Medicine disc (CBM), and Yi Maitong, and collected relevant guidelines, systematic reviews, evidence summaries, expert consensuses, and randomized controlled trials (RCTs). The retrieval time limit was from the database establishment to July 2021. The quality of the literature was independently evaluated by 2 researchers, who then extracted and summarized the evidence from qualifying articles.
A total of 16 articles were selected, including 3 guidelines, 3 systematic reviews, 5 expert consensuses, 3 RCTs, and 1 best practice guideline, including indications, time for usage, methods, monitoring and management, time of cessation, health education, and post-discharge feeding.
This study summarized the best evidence for human milk fortifier in preterm infants. Medical staff should assess the specific clinical conditions and parental wishes when applying the best evidence to ensure the effectiveness and safety of human milk fortifier, thus improving the quality of clinical nursing.
检索并收集关于早产儿母乳强化剂的证据，总结最新最佳证据，为临床工作提供参考。
检索UpToDate、美国指南网、Cochrane图书馆、乔安娜·布里格斯研究所（JBI）、PubMed、ResearchGate、中国知网（CNKI）、万方、中国生物医学文献数据库（CBM）和医脉通等数据库，收集相关指南、系统评价、证据总结、专家共识和随机对照试验（RCT）。检索时限为各数据库建库至2021年7月。由2名研究人员独立评价文献质量，然后从合格文章中提取并总结证据。
共纳入16篇文章，包括3篇指南、3篇系统评价、5篇专家共识、3篇RCT和1篇最佳实践指南，内容涵盖适应证、使用时间、方法、监测与管理、停用时间、健康教育及出院后喂养等。
本研究总结了早产儿母乳强化剂的最佳证据。医务人员在应用最佳证据时应评估具体临床情况及家长意愿，以确保母乳强化剂的有效性和安全性，从而提高临床护理质量。
