鸡生长性状的全基因组关联研究。
Genome-wide association studies for growth traits in broilers.
机构信息
Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province; College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, P. R. China.
Fujian Sunnzer Biotechnology Development Co., Ltd, Nanping, 354100, P. R. China.
出版信息
BMC Genom Data. 2022 Jan 3;23(1):1. doi: 10.1186/s12863-021-01017-7.
BACKGROUND
The identification of markers and genes for growth traits may not only benefit for marker assist selection /genomic selection but also provide important information for understanding the genetic foundation of growth traits in broilers.
RESULTS
In the current study, we estimated the genetic parameters of eight growth traits in broilers and carried out the genome-wide association studies for these growth traits. A total of 113 QTNs discovered by multiple methods together, and some genes, including ACTA1, IGF2BP1, TAPT1, LDB2, PRKCA, TGFBR2, GLI3, SLC16A7, INHBA, BAMBI, APCDD1, GPR39, and GATA4, were identified as important candidate genes for rapid growth in broilers.
CONCLUSIONS
The results of this study will provide important information for understanding the genetic foundation of growth traits in broilers.
背景
生长性状标记和基因的鉴定不仅有助于标记辅助选择/基因组选择，而且为理解肉鸡生长性状的遗传基础提供了重要信息。
结果
本研究估计了肉鸡 8 个生长性状的遗传参数，并对这些生长性状进行了全基因组关联研究。通过多种方法共发现了 113 个 QTN，其中一些基因，包括 ACTA1、IGF2BP1、TAPT1、LDB2、PRKCA、TGFBR2、GLI3、SLC16A7、INHBA、BAMBI、APCDD1、GPR39 和 GATA4，被鉴定为肉鸡快速生长的重要候选基因。
结论
本研究结果将为理解肉鸡生长性状的遗传基础提供重要信息。
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