Lu Xiaoxiang, Yang Jiajie, Xiang Yangfei
School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Cell Regen. 2022 Jan 4;11(1):1. doi: 10.1186/s13619-021-00103-6.
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells (hPSCs)-derived brain organoids are capable of recapitulating various features and functionalities of the human brain, allowing the investigation of intricate pathogenesis of developmental abnormalities. Over the past years, brain organoids have facilitated identifying disease-associated phenotypes and underlying mechanisms for human neurodevelopmental diseases. Integrating with more cutting-edge technologies, particularly gene editing, brain organoids further empower human disease modeling. Here, we review the latest progress in modeling human neurodevelopmental disorders with brain organoids.
由于大脑的复杂性及其有限的可及性，长期以来，研究人类神经发育疾病的病因一直是一项具有挑战性的任务。源自人类多能干细胞（hPSCs）的脑类器官能够重现人类大脑的各种特征和功能，从而有助于研究发育异常的复杂发病机制。在过去几年中，脑类器官推动了人类神经发育疾病相关表型和潜在机制的识别。与更前沿的技术，特别是基因编辑技术相结合，脑类器官进一步增强了人类疾病建模的能力。在此，我们综述了用脑类器官模拟人类神经发育障碍的最新进展。
