Research Competency Milestones Program (RECOMP), School of Medicine, CHA University, Seongnam-si 13488, Republic of Korea.
Department of Medicine, School of Medicine, CHA University, Seongnam-si 13496, Republic of Korea.
Int J Mol Sci. 2024 Aug 5;25(15):8540. doi: 10.3390/ijms25158540.
Damage to the central nervous system (CNS) often leads to irreversible neurological deficits, and there are currently few effective treatments available. However, recent advancements in regenerative medicine have identified CNS organoids as promising therapeutic options for addressing CNS injuries. These organoids, composed of various neurons and supporting cells, have shown potential for direct repair at injury sites. CNS organoids resemble the structure and function of actual brain tissue, which allows them to adapt and function well within the physiological environment when transplanted into injury sites. Research findings suggest that CNS organoids can replace damaged neurons, form new neural connections, and promote neural recovery. This review highlights the emerging benefits, evaluates preclinical transplantation outcomes, and explores future strategies for optimizing neuroregeneration using CNS organoids. With continued research and technological advancements, these organoids could provide new hope for patients suffering from neurological deficits.
中枢神经系统（CNS）损伤常常导致不可逆的神经功能缺损，目前有效的治疗方法寥寥无几。然而，再生医学的最新进展已经将 CNS 类器官鉴定为针对 CNS 损伤的很有前途的治疗选择。这些类器官由各种神经元和支持细胞组成，在损伤部位具有直接修复的潜力。CNS 类器官类似于实际脑组织的结构和功能，这使得它们在移植到损伤部位时能够很好地适应和在生理环境中发挥功能。研究结果表明，CNS 类器官可以替代受损的神经元，形成新的神经连接，并促进神经恢复。本综述强调了新兴的益处，评估了 CNS 类器官的临床前移植结果，并探讨了使用 CNS 类器官优化神经再生的未来策略。随着研究和技术的不断进步，这些类器官可能为患有神经功能缺损的患者带来新的希望。
