家族史、近亲结婚及其他风险因素对也门超重和肥胖成年人糖尿病前期及未诊断糖尿病患病率的影响

Family History, Consanguinity and Other Risk Factors Affecting the Prevalence of Prediabetes and Undiagnosed Diabetes Mellitus in Overweight and Obese Yemeni Adults.

作者信息

Al-Sharafi Butheinah A, Qais Ahmed A, Salem Khalil, Bashaaib Muneer O

机构信息

Department of Internal Medicine, School of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

Department of Internal Medicine, University of Science and Technology Hospital, Sana'a, Yemen.

出版信息

Diabetes Metab Syndr Obes. 2021 Dec 20;14:4853-4863. doi: 10.2147/DMSO.S344440. eCollection 2021.

DOI:10.2147/DMSO.S344440

PMID:34984017

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8709553/

Abstract

OBJECTIVE

Overweight and obese adults are at high risk for developing prediabetes and diabetes. The aim of this study was to measure the prevalence of prediabetes (pre-DM) and diabetes (DM) among Yemeni adults who were overweight or obese and had first-degree relatives with DM, consanguinity and other risk factors.

PATIENTS AND METHODS

This cross-sectional study included 612 adults, all with a BMI≥25 kg/m. BMI, blood pressure (BP) and waist circumference (WC) were measured in the clinic. Fasting blood glucose (FBG) was collected for all subjects. The patients either had first-degree relatives with diabetes or not, and the subjects answered a questionnaire regarding the consanguinity of their parents, exercise, khat chewing, smoking, and eating vegetables and fruits daily.

RESULTS

Of the 612 study participants (32% males and 68% females) aged 20-70 years old, 429 (70.1%) had a family history (FM) of DM ± consanguinity of parents, and 183 (29.9%) had no FM of diabetes. Multivariate analysis showed significant risk in those with class III obesity for pre-DM (AOR 3.10 95% CI 1.56-6.18 p value 0.001) and DM (AOR 3.35 95% CI 1.47-7.65 p value 0.004) and those who had siblings with DM had a risk for pre-DM (AOR 1.72 95% CI 1.09-2.71 p value 0.02) and DM (AOR 2.24 95% CI 1.25-4.0 p value 0.007). Khat chewing increased the risk for pre-DM (AOR 1.61 95% CI 1.04-2.48 p value 0.032) and for DM (AOR 2.09 95% CI 1.14-3.82 p value 0.017). Having consanguineous parents plus siblings with DM were associated with a higher risk of DM (p value 0.031).

CONCLUSION

There is a high prevalence of pre-DM and undiagnosed DM among overweight and obese Yemeni individuals. Class III obesity, having siblings with DM, chewing khat, and having consanguineous parents plus siblings with DM all increased the risk. This group should be screened at an early age for early detection of pre-DM and DM.

摘要

目的

超重和肥胖的成年人患糖尿病前期和糖尿病的风险很高。本研究的目的是测量也门超重或肥胖且有糖尿病一级亲属、近亲关系及其他风险因素的成年人中糖尿病前期（糖尿病前期）和糖尿病（糖尿病）的患病率。

患者与方法

这项横断面研究纳入了612名成年人，所有人的BMI均≥25kg/m²。在诊所测量BMI、血压（BP）和腰围（WC）。为所有受试者采集空腹血糖（FBG）。患者有无糖尿病一级亲属，受试者回答了一份关于其父母近亲关系、运动、嚼恰特草、吸烟以及每日食用蔬菜和水果情况的问卷。

结果

在612名年龄在20 - 70岁的研究参与者中（32%为男性，68%为女性），429人（70.1%）有糖尿病家族史（FM）±父母近亲关系，183人（29.9%）无糖尿病家族史。多因素分析显示，III级肥胖者患糖尿病前期（比值比3.10，95%置信区间1.56 - 6.18，p值0.001）和糖尿病（比值比3.35，95%置信区间1.47 - 7.65，p值0.004）的风险显著增加，有患糖尿病的兄弟姐妹的人患糖尿病前期（比值比1.72，95%置信区间1.09 - 2.71，p值0.02）和糖尿病（比值比2.24，95%置信区间1.25 - 4.0，p值0.007）的风险增加。嚼恰特草会增加患糖尿病前期（比值比1.61，95%置信区间1.04 - 2.48，p值0.032）和糖尿病（比值比2.09，95%置信区间1.14 - 3.82，p值0.0