Department of Radiology, the Second Hospital of Anhui Medical University, Hefei, Anhui 230601, China.
Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Theranostics. 2022 Jan 1;12(1):410-417. doi: 10.7150/thno.67155. eCollection 2022.
: Nowadays, magnetic resonance imaging (MRI) is routinely applied in clinical diagnosis. However, using one contrast agent (CA) to simultaneously enhance the T and T MR contrast at low and high magnetic fields respectively has not been reported. : Herein, we investigated the MR property of a γ-glutamyl transpeptidase (GGT)-instructed, intracellular formed gadolinium nanoparticle (DOTA-Gd-CBT-NP) at low and high magnetic fields. : Experimental results showed that DOTA-Gd-CBT-NP possesses a low r/r ratio 0.91 which enables it to enhance T MR imaging of liver tumor at 1.0 T, and a high r/r ratio 11.8 which renders the nanoparticle to largely enhance T MR imaging of liver tumor at 9.4 T. We expect that our GGT-responsive Gd-nanoparticle could be applied for simultaneous T and T MRI diagnosis of early liver cancer in clinic at respective low and high magnetic fields when the 9.4 T MR machine is clinically available in the future.
: 如今，磁共振成像（MRI）已常规应用于临床诊断。然而，使用一种造影剂（CA）分别在低磁场和高磁场下同时增强 T 和 T 磁共振对比尚未见报道。 : 在此，我们研究了γ-谷氨酰转肽酶（GGT）指导的、细胞内形成的钆纳米颗粒（DOTA-Gd-CBT-NP）在低磁场和高磁场下的磁共振性质。 : 实验结果表明，DOTA-Gd-CBT-NP 的 r/r 比值低（0.91），这使其能够在 1.0 T 增强肝脏肿瘤的 T 磁共振成像，r/r 比值高（11.8），这使纳米颗粒能够在 9.4 T 时大大增强肝脏肿瘤的 T 磁共振成像。我们预计，当未来 9.4 T 磁共振仪在临床上可用时，我们的 GGT 响应性 Gd 纳米颗粒可应用于分别在低磁场和高磁场下对早期肝癌进行同时 T 和 T 磁共振诊断。
