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具有增强伤口愈合功效的光波强化干细胞。

Lightwave-reinforced stem cells with enhanced wound healing efficacy.

作者信息

Kim Yu-Jin, Jeon Hye Ran, Kim Sung-Won, Kim Yeong Hwan, Im Gwang-Bum, Im Jisoo, Um Soong Ho, Cho Sung Min, Lee Ju-Ro, Kim Han Young, Joung Yoon Ki, Kim Dong-Ik, Bhang Suk Ho

机构信息

School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Gangnam-gu, Seoul, Republic of Korea.

出版信息

J Tissue Eng. 2021 Dec 18;12:20417314211067004. doi: 10.1177/20417314211067004. eCollection 2021 Jan-Dec.

DOI:10.1177/20417314211067004
PMID:34987748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8721371/
Abstract

Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.

摘要

全面的研究已在改良的人脂肪来源间充质干细胞（hADSCs）中取得了显著的临床前成果。光生物调节（PBM）作为一种增强干细胞细胞能力的技术，因其有效性和安全性而备受关注。在此，我们提出一种基于红色有机发光二极管（OLED）的PBM策略，以增强hADSCs的治疗效果。体外评估显示，与未处理的hADSCs相比，暴露于红色OLED光下的hADSCs表现出增强的血管生成、细胞粘附和迁移能力。我们证明细胞能力的增强是由于细胞内活性氧水平的升高。此外，在用红光照射的hADSCs移植的小鼠中观察到愈合加速和炎症反应得到调节。总体而言，我们的研究结果表明，基于OLED的PBM可能是一种易于获得且有吸引力的组织再生方法，可应用于各种临床干细胞治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/598c23920701/10.1177_20417314211067004-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/e9b9c5030d50/10.1177_20417314211067004-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/281e9a4ef893/10.1177_20417314211067004-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/47d2596bcd76/10.1177_20417314211067004-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/7384348b1cd4/10.1177_20417314211067004-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/ece9b44f2e07/10.1177_20417314211067004-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/598c23920701/10.1177_20417314211067004-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/e9b9c5030d50/10.1177_20417314211067004-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/281e9a4ef893/10.1177_20417314211067004-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/47d2596bcd76/10.1177_20417314211067004-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/7384348b1cd4/10.1177_20417314211067004-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/ece9b44f2e07/10.1177_20417314211067004-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/8721371/598c23920701/10.1177_20417314211067004-fig6.jpg

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