Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Sci Adv. 2021 Jan 22;7(4). doi: 10.1126/sciadv.abe7174. Print 2021 Jan.
The major impediments to the implementation of cancer immunotherapies are the sustained immune effect and the targeted delivery of these therapeutics, as they have life-threatening adverse effects. In this work, biomimetic metal-organic frameworks [zeolitic imidazolate frameworks (ZIFs)] are used for the controlled delivery of nivolumab (NV), a monoclonal antibody checkpoint inhibitor that was U.S. Food and Drug Administration-approved back in 2014. The sustained release behavior of NV-ZIF has shown a higher efficacy than the naked NV to activate T cells in hematological malignancies. The system was further modified by coating NV-ZIF with cancer cell membrane to enable tumor-specific targeted delivery while treating solid tumors. We envisage that such a biocompatible and biodegradable immunotherapeutic delivery system may promote the development and the translation of hybrid superstructures into smart and personalized delivery platforms.
癌症免疫疗法实施的主要障碍是这些疗法的持续免疫效应和靶向递送，因为它们有危及生命的不良反应。在这项工作中，仿生金属-有机框架[沸石咪唑酯骨架（ZIFs）]被用于控制递送纳武单抗（NV），这是一种单克隆抗体检查点抑制剂，早在 2014 年就获得了美国食品和药物管理局的批准。NV-ZIF 的持续释放行为显示出比裸 NV 更高的功效，能够激活血液系统恶性肿瘤中的 T 细胞。该系统进一步通过用癌细胞膜包覆 NV-ZIF 进行修饰，以实现针对实体瘤的肿瘤特异性靶向递送。我们设想，这种具有生物相容性和可生物降解性的免疫治疗药物递送系统可能会促进混合超结构向智能和个性化递送平台的发展和转化。
