Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, 304022, India.
Biol Trace Elem Res. 2022 Dec;200(12):5328-5350. doi: 10.1007/s12011-021-03092-4. Epub 2022 Jan 7.
The gut microbiota has a vital role in the maintenance of intestinal homeostasis. Several studies have revealed that environmental exposure to pollutants such as heavy metals may contribute to the progression of extensive list of diseases which may further lead to perturbations in the gut leading to dysbiosis. This manuscript critically reviews the alterations in the gut microbiota composition and function upon exposure to various toxic heavy metals prevalent in the environment. The disturbance in gut microbial ecology also affects the microbial metabolic profile which may alter the speciation state and bioavailability heavy metals thus affecting metal uptake-absorption/detoxification mechanisms associated to heavy metal metabolism. The toxic effects of various heavy metals either in single or in multimetallic combination and the gut microbiota associated host health and disease condition need a comprehensive assessment with important consideration for therapeutic and protective strategies against the damage to gut microbiota.
肠道微生物群在维持肠道内环境稳定方面起着至关重要的作用。多项研究表明，环境暴露于污染物，如重金属，可能导致广泛的疾病进展，而这些疾病可能进一步导致肠道紊乱，从而导致肠道微生态失调。本文批判性地回顾了暴露于环境中常见的各种有毒重金属后，肠道微生物群落组成和功能的变化。肠道微生物生态的紊乱也会影响微生物的代谢谱，从而改变重金属的形态和生物利用度，进而影响与重金属代谢相关的金属摄取、吸收/解毒机制。各种重金属无论是单一存在还是多种金属组合存在，以及与肠道微生物群相关的宿主健康和疾病状况，都需要进行全面评估，并考虑针对肠道微生物群损伤的治疗和保护策略。
