Chen Cheng
Vascular Surgery, Yunnan Fuwai Cardiovascular Hospital, Kunming, 650000, Yunnan, China.
Appl Biochem Biotechnol. 2022 May;194(5):1911-1924. doi: 10.1007/s12010-021-03735-1. Epub 2022 Jan 8.
Hypercholesterolemia is a well-known etiological feature for cardiovascular diseases and a common indication of maximum categories of metabolic disorders. Para methoxy cinnamic acid is one of the cinnamic acid derivatives as a natural product obtained from the rice bran oil as an active constituent and has the antioxidant property. The present study was designed to evaluate the hypolipidemic activity of P-methoxy cinnamic acid against high fat diet induced hyperlipidemia in experimental rats. Male Wistar albino rats were divided into five groups (n = 6), and high fat diet was used to induce the hyperlipidemia for 28 days. P-methoxy cinnamic acid was used in two different doses (40 and 80 mg/kg body weight), and they were administered orally to the rats for 28 days during high fat diet. Atorvastatin (5 mg/kg) was used as reference standard. A significant elevated level of lipid abnormalities and tissue antioxidant parameters were reversed from normal level by the treatment of P-methoxy cinnamic acid in both the doses. Histopathological evidence further supported the protective action. Based on the initial findings, it was concluded that P-methoxy cinnamic acid was able to offer significant protection against high fat diet induced atherosclerosis. Future studies were recommended to identify the molecular mechanism of P-methoxy cinnamic acid against atherosclerosis protection.
高胆固醇血症是心血管疾病众所周知的病因特征，也是大多数代谢紊乱的常见指征。对甲氧基肉桂酸是肉桂酸衍生物之一，作为从米糠油中获得的天然产物的活性成分，具有抗氧化特性。本研究旨在评估对甲氧基肉桂酸对高脂饮食诱导的实验性大鼠高脂血症的降血脂活性。雄性Wistar白化大鼠分为五组（n = 6），采用高脂饮食诱导高脂血症28天。对甲氧基肉桂酸以两种不同剂量（40和80毫克/千克体重）使用，并在高脂饮食期间对大鼠口服给药28天。阿托伐他汀（5毫克/千克）用作参考标准。两种剂量的对甲氧基肉桂酸治疗均使脂质异常和组织抗氧化参数的显著升高水平从正常水平逆转。组织病理学证据进一步支持了这种保护作用。基于初步研究结果，得出结论：对甲氧基肉桂酸能够对高脂饮食诱导的动脉粥样硬化提供显著保护。建议未来的研究确定对甲氧基肉桂酸抗动脉粥样硬化保护作用的分子机制。
