Yang Fan, Zhang Qi, Yuan Zhongshang, Teng Saisai, Cui Lizhen, Xue Fuzhong, Wei Leyi
Department of Epidemiology and Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Pharmacol. 2021 Dec 24;12:759479. doi: 10.3389/fphar.2021.759479. eCollection 2021.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has aggressed in more than 200 countries and territories since Dec 2019, and 30 million cases of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 have been reported, including 950,000 deaths. Supportive treatment remains the mainstay of therapy for COVID-19. There are no small-molecule-specific antiviral drugs available to prevent and treat COVID-19 until recently. Herbal medicine can facilitate syndrome differentiation and treatment according to the clinical manifestations of patients and has demonstrated effectiveness in epidemic prevention and control. The National Health Commission (NHC) of China has recommended "three TCM prescriptions and three medicines," as a group of six effective herbal formulas against COVID-19 in the released official file "Diagnosis and Treatment Protocol for COVID-19 Patients: Herbal Medicine for the Priority Treatment of COVID-19." This study aimed to develop a collaborative filtering approach to signaling drug combinations that are similar to the six herbal formulas as potential therapeutic treatments for treating COVID-19. The results have been evaluated by herbal medicine experts' domain knowledge.
自2019年12月以来，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已侵袭200多个国家和地区，据报告，由SARS-CoV-2引起的2019冠状病毒病（COVID-19）病例达3000万例，其中死亡95万例。支持性治疗仍然是COVID-19治疗的主要手段。直到最近，仍没有可用于预防和治疗COVID-19的小分子特异性抗病毒药物。中药可根据患者临床表现进行辨证论治，在疫情防控中已显示出有效性。中国国家卫生健康委员会（NHC）在发布的官方文件《新型冠状病毒肺炎诊疗方案：中医药治疗部分》中推荐了“三药三方”，作为一组针对COVID-19的六种有效中药方剂。本研究旨在开发一种协同过滤方法，以筛选出与这六种中药方剂相似的药物组合，作为治疗COVID-19的潜在治疗方法。研究结果已由中药专家的领域知识进行评估。
