National Traditional Chinese Medicine Clinical Research Base, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, China; Drug Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China.
National Traditional Chinese Medicine Clinical Research Base, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, China.
Biomed Pharmacother. 2021 May;137:111310. doi: 10.1016/j.biopha.2021.111310. Epub 2021 Feb 3.
Currently, the number of confirmed cases and deaths of COVID-19 worldwide continues to rise, receiving great concern from the international community. However, there is no specific and widely accepted effective vaccines. The experience in controlling the outbreak in China has proven the effectiveness of traditional Chinese medicine (TCM).
This review aims to evaluate the role of TCM in COVID-19 treatment, hoping to provide references for prevention and control of global pandemic.
China National Knowledge Infrastructure, Web of Science, Baidu Scholar, ScienceDirect, Elsevier and PubMed were used to search literatures published from December 2019 to December 2020 by entering the keywords "Traditional Chinese medicine", "COVID-19″, "Severe acute respiratory syndrome coronavirus 2″, "Pathogenesis", "Syndrome differentiation", "Prescriptions" and their combinations. Hence, we have performed an extensive review of research articles, reviews and primary scientific studies to identify TCM against COVID-19.
Among clinical treatments of COVID-19, several TCM prescriptions and characteristic therapies have been effectively suggested, the underlying mechanisms of which are mainly involved in antiviral, anti-inflammatory, immunomodulatory and organ-protective effects of multi-components acting on multi-targets at multi-pathways.
This review may provide meaningful and feasible information that can be considered for the treatment of COVID-19 pandemic globally.
目前，全球新冠肺炎确诊病例和死亡人数持续上升，引起国际社会高度关注。然而，目前尚无特效药物和广泛认可的有效疫苗。中国在疫情防控中积累的经验证明了中医药的有效性。
评价中医药在新冠肺炎治疗中的作用，为全球疫情防控提供参考。
检索 2019 年 12 月至 2020 年 12 月期间在中国国家知识基础设施、Web of Science、百度学术、ScienceDirect、爱思唯尔和 PubMed 数据库中以“Traditional Chinese medicine”“COVID-19”“Severe acute respiratory syndrome coronavirus 2”“Pathogenesis”“Syndrome differentiation”“Prescriptions”为关键词，结合其他相关关键词组合，对中医药治疗新冠肺炎的相关文献进行检索。因此，我们对研究论文、综述和初步科学研究进行了广泛的回顾，以确定中医药防治新冠肺炎的作用。
在新冠肺炎的临床治疗中，提出了几种有效的中药方剂和特色疗法，其作用机制主要涉及抗病毒、抗炎、免疫调节和多成分多靶点多途径的器官保护作用。
本综述可为全球新冠肺炎大流行的治疗提供有意义且可行的信息。
