基于聚-N-乙烯基咪唑的原始铜纳米复合材料的安全性和毒性评估。

Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole.

作者信息

Shurygina Irina A, Prozorova Galina F, Trukhan Irina S, Korzhova Svetlana A, Dremina Nataliya N, Emel'yanov Artem I, Say Olesya V, Kuznetsova Nadezhda P, Pozdnyakov Alexander S, Shurygin Michael G

机构信息

Irkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.

A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.

出版信息

Nanomaterials (Basel). 2021 Dec 22;12(1):16. doi: 10.3390/nano12010016.

DOI:10.3390/nano12010016

PMID:35009966

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8746882/

Abstract

A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium. The synthesized new water-soluble copper-containing nanocomposite is promising for biotechnological and biomedical research as a new non-toxic hydrophilic preparation that is allowed to regulate the work of key enzymes involved in energy metabolism and antioxidant protection as well as potentially serving as an additional source of copper.

摘要

合成了一种基于聚-N-乙烯基咪唑的新型原创铜纳米复合材料，并通过一系列现代物理化学和生物学方法进行了表征。发现该铜纳米复合材料对培养的肝细胞具有低细胞毒性。在用添加到营养培养基中的这种纳米复合材料孵育肝细胞培养物的过程中，评估了纳米复合材料中的铜参与铜依赖性酶系统功能的可能性。合成的新型水溶性含铜纳米复合材料作为一种新型无毒亲水性制剂，有望用于生物技术和生物医学研究，它可以调节参与能量代谢和抗氧化保护的关键酶的活性，并且有可能作为铜的额外来源。