化学特征分析、生物活性评估及 CBS 113139 产生的新型生物色素的发现。
Chemical Profiling, Bioactivity Evaluation and the Discovery of a Novel Biopigment Produced by CBS 113139.
机构信息
Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece.
Department of Food Science and Human Nutrition, Agricultural University of Athens, 118 55 Athens, Greece.
出版信息
Molecules. 2021 Dec 23;27(1):69. doi: 10.3390/molecules27010069.
Biobased pigments are environmentally friendly alternatives to synthetic variants with an increased market demand. Production of pigments via fermentation is a promising process, yet optimization of the production yield and rate is crucial. Herein, we evaluated the potential of to produce biobased pigments. Optimum sugar concentration was 30 g/L and optimum C:N ratio was 36:1 resulting in the production of 4.1-4.5 AU (namely Pigment Complex A). Supplementation with ammonium nitrate resulted in the production of 4.1-4.9 AU (namely Pigment Complex B). Pigments showed excellent pH stability. The major biopigments in Pigment Complex A were or the acid form of (red pigment), (violet pigment), (orange pigment) and . In Pigment Complex B, a novel biopigment annotated as was identified. Its basic structure contains a polyketide azaphilone with the same carboxyl-monascorubramine base structure as (violet pigment) and . The pigments were not cytotoxic up to 250 μg/mL.
生物基颜料是对环境友好的合成变体替代品，市场需求不断增加。通过发酵生产颜料是一种很有前途的工艺，但提高生产产量和速度至关重要。在此，我们评估了 生产生物基颜料的潜力。最佳糖浓度为 30 g/L，最佳 C:N 比为 36:1，可生产 4.1-4.5 AU（即色素复合物 A）。添加硝酸铵可生产 4.1-4.9 AU（即色素复合物 B）。色素显示出极好的 pH 稳定性。色素复合物 A 中的主要生物颜料是 或 （红色颜料）、 （紫色颜料）、 （橙色颜料）和 。在色素复合物 B 中，鉴定出一种新型生物颜料，注释为 。其基本结构含有一个聚酮类氮杂菲酮，其羧基-单乳rubramine 碱基结构与 （紫色颜料）和 相同。这些颜料在高达 250 μg/mL 的浓度下没有细胞毒性。
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