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急性A型主动脉夹层中半弓置换与全弓置换:奥卡姆剃刀原理是否适用?

Hemiarch Versus Arch Replacement in Acute Type A Aortic Dissection: Is the Occam's Razor Principle Applicable?

作者信息

Vendramin Igor, Piani Daniela, Lechiancole Andrea, Sponga Sandro, Di Nora Concetta, Londero Francesco, Muser Daniele, Onorati Francesco, Bortolotti Uberto, Livi Ugolino

机构信息

Division of Cardiac Surgery, Cardiothoracic Department, University Hospital of Udine, 33100 Udine, Italy.

Division of Cardiology, Cardiothoracic Department, University Hospital of Udine, 33100 Udine, Italy.

出版信息

J Clin Med. 2021 Dec 26;11(1):114. doi: 10.3390/jcm11010114.

Abstract

BACKGROUND AND AIM OF THE STUDY

In patients with acute Type A aortic dissection (A-AAD) whether repair should be limited to ascending aorta/hemiarch replacement or extended to include the aortic arch is still debated. We have analyzed our experience to compare outcomes of patients with A-AAD treated with these 2 different surgical strategies.

METHODS

From 2006 to 2020, a total of 213 patients have undergone repair of A-AAD at our Center; in 163 of them ascending aorta/hemiarch replacement (Group 1) and in 75 ascending aorta and arch replacement (Group 2) were performed. The primary endpoint was early survival and secondary endpoints late survival, freedom from late complications and reoperations. Patients were compared according to era of operation: 2006 to 2013 (Era 1) and 2014 to 2020 (Era 2).

RESULTS

Overall hospital mortality was 12% and 5% in Group 1 and 2; mortality remained stable in Era 1 and 2 for Group 1 (15%), while it decreased from 8% to 1% in Group 2 patients ( = 0.24). Actuarial survival at 5 and 10 years is 72 ± 4% and 49 ± 5% in Group 1 and 77 ± 6% and 66 ± 9% in Group 2 ( = 0.073). Actuarial freedom from reoperation in the entire series is 94 ± 2% and 92 ± 3% at 5 and 10 years. Freedom from reoperation at 5 and 10 years is 92 ± 2% and 89 ± 3% in Group 1 and 98 ± 1% at all intervals in Group 2 ( = 0.068).

CONCLUSIONS

An aggressive approach to A-AAD provides superior long-term results without increasing mortality. Furthermore, arch replacement during A-AAD repair represents a more stable solution with lower incidence of late aortic-related complications. Immediate aortic arch replacement should be considered in the treatment of A-AAD especially in experienced centers.

摘要

研究背景与目的

对于急性A型主动脉夹层(A-AAD)患者,手术修复是应局限于升主动脉/半弓置换,还是应扩展至包括主动脉弓,目前仍存在争议。我们分析了我们的经验,以比较采用这两种不同手术策略治疗的A-AAD患者的预后。

方法

2006年至2020年,共有213例患者在我们中心接受了A-AAD修复手术;其中163例行升主动脉/半弓置换术(第1组),75例行升主动脉和主动脉弓置换术(第2组)。主要终点是早期生存率,次要终点是晚期生存率、无晚期并发症生存率和再次手术率。根据手术年代对患者进行比较:2006年至2013年(第1阶段)和2014年至2020年(第2阶段)。

结果

第1组和第2组的总体医院死亡率分别为12%和5%;第1组在第1阶段和第2阶段的死亡率保持稳定(15%),而第2组患者的死亡率从8%降至1%(P = 0.24)。第1组5年和10年的精算生存率分别为72±4%和49±5%,第2组分别为77±6%和66±9%(P = 0.073)。整个系列在5年和10年的再次手术精算无发生率分别为94±2%和92±3%。第1组5年和10年的再次手术无发生率分别为92±2%和89±3%,第2组在所有随访期的再次手术无发生率为98±1%(P = 0.068)。

结论

对A-AAD采取积极的手术方法可提供更好的长期预后,且不增加死亡率。此外,在A-AAD修复术中进行主动脉弓置换是一种更稳定的解决方案,晚期主动脉相关并发症的发生率更低。在A-AAD的治疗中,尤其是在经验丰富的中心,应考虑立即进行主动脉弓置换。

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