Nutrition and Food Science Area, Faculty of Pharmacy, University of Valencia, Avda. Vicent Andrés Estellés s/n, Burjassot, Valencia 46100, Spain.
Clinical Biochemistry, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, C/Manuel de Falla, 1, Madrid 28222, Spain.
J Agric Food Chem. 2022 Jan 19;70(2):532-542. doi: 10.1021/acs.jafc.1c06120. Epub 2022 Jan 11.
In the present study, the impact of galactooligosaccharide (GOS) addition to a plant sterol (PS)-enriched beverage on the hypocholesterolemic effect and on the bioavailability and colonic metabolization of sterols was evaluated. A crossover trial was undertaken in postmenopausal women who intook a PS-enriched (2 g PS/day) or PS-GOS-enriched beverage (2 g PS/day and 4.3 g GOS/day) for 6 weeks. The presence of GOS did not modify the hypocholesterolemic effect of the PS-enriched beverage (total- and low-density lipoprotein-cholesterol reductions) or sterol bioavailability (increments of serum markers of dietary PS intake and of cholesterol synthesis). The consumption of both beverages led to an increase of sterol and metabolite excretion (with the exception of coprostanol, which decreased) and to slight changes in women's capacities for sterol conversion, regardless of the GOS presence. This study demonstrates the suitability of simultaneous enrichment with PS and GOS in milk-based fruit beverages, considering their hypocholesterolemic effect.
在本研究中，评估了在富含植物固醇（PS）的饮料中添加半乳糖寡糖（GOS）对降胆固醇作用以及固醇的生物利用度和结肠代谢的影响。对绝经后妇女进行了一项交叉试验，这些妇女饮用富含 PS（每天 2 克 PS）或 PS-GOS 富含的饮料（每天 2 克 PS 和 4.3 克 GOS），持续 6 周。GOS 的存在并未改变富含 PS 的饮料的降胆固醇作用（总胆固醇和低密度脂蛋白胆固醇降低）或固醇的生物利用度（饮食 PS 摄入和胆固醇合成的血清标志物增加）。两种饮料的摄入均导致固醇和代谢物排泄增加（除粪甾烷醇减少外），并且无论是否存在 GOS，女性的固醇转化能力均略有变化。考虑到其降胆固醇作用，本研究证明了在基于牛奶的水果饮料中同时添加 PS 和 GOS 的适宜性。
