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基于实验室和现场研究的灵长类疟疾按蚊媒介的血粉分析。

Blood meal analysis of Anopheles vectors of simian malaria based on laboratory and field studies.

机构信息

Department of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia.

出版信息

Sci Rep. 2022 Jan 10;12(1):354. doi: 10.1038/s41598-021-04106-w.

DOI:10.1038/s41598-021-04106-w
PMID:35013403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8748441/
Abstract

Blood feeding and host-seeking behaviors of a mosquito play an imperative role in determining its vectorial capacity in transmitting pathogens. Unfortunately, limited information is available regarding blood feeding behavior of Anopheles species in Malaysia. Collection of resting Anopheles mosquitoes for blood meal analysis poses a great challenge especially for forest dwelling mosquitoes. Therefore, a laboratory-based study was conducted to evaluate the potential use of mosquitoes caught using human landing catch (HLC) for blood meal analysis, and subsequently to document blood feeding behavior of local Anopheles mosquitoes in Peninsular Malaysia. The laboratory-based experiment from this study revealed that mosquitoes caught using HLC had the potential to be used for blood meal analysis. Besides HLC, mosquitoes were also collected using manual aspirator and Mosquito Magnet. Overall, 47.4% of 321 field-caught Anopheles mosquitoes belonging to six species were positive for vertebrate host DNA in their blood meal. The most frequent blood meal source was human (45.9%) followed by wild boar (27.4%), dog (15.3%) and monkey (7.5%). Interestingly, only Anopheles cracens and Anopheles introlatus (Leucosphyrus Group) fed on monkey. This study further confirmed that members of the Leucosphyrus Group are the predominant vectors for knowlesi malaria transmission in Peninsular Malaysia mainly due to their simio-anthropophagic feeding behavior.

摘要

血液摄取和宿主寻找行为在确定蚊子传播病原体的媒介能力方面起着至关重要的作用。不幸的是，有关马来西亚按蚊属物种血液摄取行为的信息有限。收集休息的按蚊进行血液餐分析带来了巨大的挑战，尤其是对于森林栖居的蚊子。因此，进行了一项基于实验室的研究，以评估使用人体诱捕（HLC）捕获的蚊子进行血液餐分析的潜力，并随后记录马来西亚半岛当地按蚊的血液摄取行为。本研究的实验室实验表明，使用 HLC 捕获的蚊子有可能用于血液餐分析。除了 HLC 之外，还使用手动吸气器和 Mosquito Magnet 收集蚊子。总的来说，在 321 只野外捕获的属于六个物种的按蚊中，有 47.4%的蚊子血液餐中检测到脊椎动物宿主 DNA 呈阳性。最常见的血液餐来源是人类（45.9%），其次是野猪（27.4%）、狗（15.3%）和猴子（7.5%）。有趣的是，只有安蚊属和按蚊属（白环组）以猴子为食。这项研究进一步证实，白环组的成员是马来西亚半岛已知疟疾病毒传播的主要媒介，主要是因为它们具有类似人-捕食性的取食行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e3/8748441/2f18deb034ce/41598_2021_4106_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e3/8748441/4fcdb3fa48ab/41598_2021_4106_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e3/8748441/2f18deb034ce/41598_2021_4106_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e3/8748441/4fcdb3fa48ab/41598_2021_4106_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e3/8748441/f38a53b80700/41598_2021_4106_Fig2_HTML.jpg
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