Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Mediterranea Cardiocentro, Napoli, Italy.
Sci Rep. 2022 Jan 10;12(1):385. doi: 10.1038/s41598-021-04344-y.
The immune response after SARS-CoV-2 vaccine administration appears to be characterized by high inter-individual variation, even in SARS-CoV-2 positive subjects, who could have experienced different post-infection, unresolved conditions. We monitored anti-SARS-CoV-2 IgG levels and kinetics along with circulating biomarkers in a cohort of 175 healthcare workers during early immunization with COVID-19 mRNA-LNP BNT162b2 vaccine, to identify the associated factors. Subjects with a previous SARS-CoV-2 infection were characterized by higher BMI and CRP levels and lower neutrophil count with respect to naïve subjects. Baseline IgG levels resulted associated with CRP independently on BMI and inflammatory diseases. Among 137 subjects undergoing vaccination and monitored after the first and the second dose, three kinetic patterns were identified. The pattern showing a rapid growth was characterized by higher IgG levels at baseline and higher CRP and MCHC levels than negative subjects. Subjects previously exposed to SARS-CoV-2 showed higher levels of CRP, suggesting persistence of unresolved inflammation. These levels are the main determinant of IgG levels at baseline and characterized subjects belonging to the best performing, post-vaccine antibody kinetic pattern.
接种 SARS-CoV-2 疫苗后的免疫反应似乎具有高度的个体间变异性，即使在 SARS-CoV-2 阳性的受试者中也是如此，这些受试者可能经历了不同的感染后、未解决的情况。我们在 COVID-19 mRNA-LNP BNT162b2 疫苗早期免疫接种期间监测了 175 名医护人员的抗 SARS-CoV-2 IgG 水平和动力学以及循环生物标志物，以确定相关因素。与初免者相比，有 SARS-CoV-2 既往感染史的受试者 BMI 和 CRP 水平较高，中性粒细胞计数较低。基线 IgG 水平与 CRP 独立于 BMI 和炎症性疾病相关。在 137 名接受疫苗接种并在第一剂和第二剂后进行监测的受试者中，确定了三种动力学模式。快速增长模式的特点是基线 IgG 水平较高，CRP 和 MCHC 水平高于阴性受试者。既往暴露于 SARS-CoV-2 的受试者 CRP 水平较高，表明持续存在未解决的炎症。这些水平是基线 IgG 水平的主要决定因素，并描述了属于最佳疫苗抗体动力学模式的受试者。
