一名新冠病毒检测呈阳性的患者，在长期使用糖皮质激素的情况下发生播散性隐球菌感染和脑膜脑炎致死病例。
Fatal case of disseminated cryptococcal infection and meningoencephalitis in the setting of prolonged glucocorticoid use in a Covid-19 positive patient.
作者信息
Karnik Krupa, Wu Yuexiu, Ruddy Samantha, Quijano-Rondan Bladimir, Urban Carl, Turett Glenn, Yung Lok, Prasad Nishant, Yoon James, Segal-Maurer Sorana
机构信息
The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main St, Flushing, New York 11355, United States.
Department of Medicine, NewYork-Presbyterian Queens, 56-45 Main St, Flushing, New York 11355, United States.
出版信息
IDCases. 2022;27:e01380. doi: 10.1016/j.idcr.2022.e01380. Epub 2022 Jan 6.
Abstract
Based on the RECOVERY trial, glucocorticoids have become the mainstay of treatment for COVID-19, thus increasing the risk of opportunistic infections. We report a case of disseminated with documented meningoencephalitis in a patient with severe COVID-19 in the setting of prolonged glucocorticoid administration with poor outcome likely due to adrenal involvement.
摘要
基于RECOVERY试验，糖皮质激素已成为治疗新冠肺炎的主要药物，从而增加了机会性感染的风险。我们报告了一例在长期使用糖皮质激素治疗的重症新冠肺炎患者中发生播散性感染并伴有记录在案的脑膜脑炎的病例，其预后不良可能是由于肾上腺受累。
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2
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3
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