Zhang Ruohao, Yu Jie, Ma Kun, Ma Yufan, Wang Zhuo
State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
ACS Appl Bio Mater. 2020 Oct 19;3(10):7168-7177. doi: 10.1021/acsabm.0c00979. Epub 2020 Sep 30.
With the increasing threat of bacterial infection to human health, the development of different antimicrobial agents is essential. Therefore, based on the photothermal conversion properties of gold nanomaterials, the polyelectrolyte (PE)-coated gold nanorods (GNR@PE) and gold nanostars (GNS@PE) are designed and synthesized. Consequently, the chemo-photothermal synergistic antibacterial effect is achieved. GNR@PE effectively eliminates the high toxicity of cetyltrimethylammonium bromide (CTAB), and both GNR@PE and GNS@PE have good biocompatibility and stability. Because of the cation coating, GNR@PE and GNS@PE show high localized surface charge, which causes strong affinity to bacteria and destruction of bacterial cell walls and cell membranes. They have good chemical antibacterial effects, and the chemical antibacterial rates are above 50%. Under the irradiation of an 808 nm laser, for Gram-negative bacteria and Gram-positive bacteria, GNR@PE (50.00 μg/mL) and GNS@PE (55.00 μg/mL) can kill more than 99% of bacteria through chemo-photothermal effects. GNR@PE and GNS@PE can help eliminate inflammation caused by infection and promote wound healing in the mice model and have few side effects on the organs of mice.
随着细菌感染对人类健康的威胁日益增加，开发不同的抗菌剂至关重要。因此，基于金纳米材料的光热转换特性，设计并合成了聚电解质（PE）包覆的金纳米棒（GNR@PE）和金纳米星（GNS@PE）。从而实现了化学-光热协同抗菌效果。GNR@PE有效消除了十六烷基三甲基溴化铵（CTAB）的高毒性，GNR@PE和GNS@PE均具有良好的生物相容性和稳定性。由于阳离子涂层，GNR@PE和GNS@PE表现出高局部表面电荷，这导致对细菌具有强烈亲和力并破坏细菌细胞壁和细胞膜。它们具有良好的化学抗菌效果，化学抗菌率超过50%。在808 nm激光照射下，对于革兰氏阴性菌和革兰氏阳性菌，GNR@PE（50.00 μg/mL）和GNS@PE（55.00 μg/mL）可通过化学-光热效应杀死超过99%的细菌。GNR@PE和GNS@PE有助于消除感染引起的炎症，并促进小鼠模型中的伤口愈合，对小鼠器官几乎没有副作用。
