Biswas Kunal, Mishra Awdhesh Kumar, Rauta Pradipta Ranjan, Al-Sehemi Abdullah G, Pannipara Mehboobali, Sett Avik, Bratovcic Amra, Avula Satya Kumar, Mohanta Tapan Kumar, Saravanan Muthupandian, Mohanta Yugal Kishore
Centre for Nanoscience and Nanotechnology, Sathyabama Institute of Science and Technology (Formerly Sathyabama University), Jeppiar Nagar, Salai, Chennai 600119, India.
Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, Korea.
Int J Mol Sci. 2022 Jan 10;23(2):714. doi: 10.3390/ijms23020714.
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm, 1023 cm, 1400 cm for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime.
目前,已在体外生物系统中评估了AgNPs/内富勒烯分子金属纳米复合材料的潜在作用。已在体外研究了富勒烯分子(C)的原子内构型对人乳腺腺癌(MDA-MB-231)细胞系的抗增殖活性以及对一些人类病原体的抗菌活性,这些病原体因原始表面等离子体电子和AgNPs的抗生素活性而增强。此外,傅里叶变换红外光谱(FTIR)分别揭示了C分子的碳和氧原子的O-H、C-O和C-H基团在约3300 cm、1023 cm、1400 cm处的基本振动特征。核磁共振(NMR)研究显示在约7.285 ppm处有不同的信号特征和磁矩,解释了富勒烯分子独特的潜在电化学属性。笼状碳结构的这种独特电子和物理化学性质为其在药物递送领域的应用带来了希望。C的体外剂量依赖性应用对乳腺腺癌细胞系和致病微生物均引发毒性反应。这使得未来可以利用AgNPs修饰的C内富勒烯分子设计有效的抗癌药物递送和抗菌剂,给治疗方案带来革命性变化。