Ultrasound Diagnosis Department, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang City, Jiangxi Province, People's Republic of China.
General Surgery, Leping people's Hospital, Phoenix Avenue, Leping, Jiangxi Province, People's Republic of China.
Biotechnol Appl Biochem. 2021 Dec;68(6):1236-1242. doi: 10.1002/bab.2045. Epub 2020 Oct 11.
Recent developments in nanotechnology promoted the production of nanomaterials with various shapes and sizes by utilizing interdisciplinary researches of biology, chemistry, and material science toward the clinical perspectives. In particular, gold and silver (Ag) are noble metals that exhibit tunable and unique plasmonic properties for the downstream applications. Ag exhibits higher thermal and electrical conductivities, and more efficient in the electron transfer than gold with sharper extinction bands. In addition, modified Ag nanoparticle is more stable in water and air. With all these above features, Ag is an attractive tool in various fields, including diagnosis, drug delivery, environmental, electronics, and as antimicrobial agent. In particular, applications of Ag nanoparticle in the fields of biosensor and imaging are prominent in recent days. Enhancing the specific detection of clinical markers with Ag nanoparticle has been proved by several studies. This review discussed the constructive application of Ag nanoparticle in biosensor and bioimaging for the detection of small molecule to larger whole cell in the perspectives of diagnosing diseases.
近年来，纳米技术的发展促进了各种形状和尺寸的纳米材料的生产，利用生物学、化学和材料科学的交叉研究，朝着临床应用的方向发展。特别是金和银（Ag）是贵金属，它们具有可调谐和独特的等离子体特性，可用于下游应用。Ag 具有更高的热导率和电导率，电子转移效率也比金更高，消光带更尖锐。此外，修饰后的 Ag 纳米颗粒在水中和空气中更稳定。由于具有所有这些特性，Ag 在包括诊断、药物输送、环境、电子和抗菌剂在内的各个领域都是一种有吸引力的工具。特别是，Ag 纳米颗粒在生物传感器和成像领域的应用在最近几天变得非常突出。几项研究已经证明，Ag 纳米颗粒在增强对临床标志物的特异性检测方面具有重要作用。本综述从诊断疾病的角度讨论了 Ag 纳米颗粒在生物传感器和生物成像中的建设性应用，用于检测小分子到更大的整个细胞。
