"Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Clinical Emergency Eye Hospital, 030167 Bucharest, Romania.
J Diabetes Res. 2022 Jan 19;2022:1516668. doi: 10.1155/2022/1516668. eCollection 2022.
The current research approaches the retinal microvasculature of healthy volunteers (17 subjects), patients with diabetes mellitus without retinopathy (19 subjects), and of diabetic patients with nonproliferative (17 subjects) and proliferative (21 subjects) diabetic retinopathy, by using adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography. For each imaging technique, several vascular parameters have been calculated in order to achieve a comparative analysis of these imaging biomarkers between the four studied groups. The results suggest that diabetic patients with or without diabetic retinopathy prove signs of retinal arteriole structural alterations, mainly showed by altered values of wall to lumen ratio, calculated for the superior or inferior temporal branch of the central retinal artery, near the optic nerve head, and significant changes of the vascular density in the retinal superficial capillary plexus. Both adaptive optics ophthalmoscopy and optical coherence ophthalmoscopy angiography are providing useful information about the retinal microvasculature from early onset of diabetic disease, having a promising diagnostic and prognostic role in the future.
本研究采用自适应光学眼底镜和光相干断层扫描血管造影术对健康志愿者（17 名受试者）、无糖尿病视网膜病变的糖尿病患者（19 名受试者）、非增生性（17 名受试者）和增生性（21 名受试者）糖尿病视网膜病变患者的视网膜微血管进行了研究。为了比较这四种研究组之间的这些成像生物标志物，针对每种成像技术计算了几个血管参数。结果表明，有或没有糖尿病视网膜病变的糖尿病患者表现出视网膜小动脉结构改变的迹象，主要表现为视神经头附近视网膜中央动脉上或下颞支的壁腔比计算值发生改变，以及视网膜浅层毛细血管丛的血管密度发生显著变化。自适应光学眼底镜和光相干断层扫描血管造影术都可以提供关于糖尿病早期视网膜微血管的有用信息，在未来具有有希望的诊断和预后作用。
