用于肺部多中心临床磁共振成像的独立便携式氙气-129 极化器。
Standalone portable xenon-129 hyperpolariser for multicentre clinical magnetic resonance imaging of the lungs.
机构信息
POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Department of Radiology, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
出版信息
Br J Radiol. 2022 Apr 1;95(1132):20210872. doi: 10.1259/bjr.20210872. Epub 2022 Jan 31.
OBJECTIVES
Design and build a portable xenon-129 (Xe) hyperpolariser for clinically accessible Xe lung MRI.
METHODS
The polariser system consists of six main functional components: (i) a laser diode array and optics; (ii) a B coil assembly; (iii) an oven containing an optical cell; (iv) NMR and optical spectrometers; (v) a gas-handling manifold; and (vi) a cryostat within a permanent magnet. All components run without external utilities such as compressed air or three-phase electricity, and require just three mains sockets for operation. The system can be manually transported in a lightweight van and rapidly installed on a small estates footprint in a hospital setting.
RESULTS
The polariser routinely provides polarised Xe for routine clinical lung MRI. To test the concept of portability and rapid deployment, it was transported 200 km, installed at a hospital with no previous experience with the technology and Xe MR images of a diagnostic quality were acquired the day after system transport and installation.
CONCLUSION
This portable Xe hyperpolariser system could form the basis of a cost-effective platform for wider clinical dissemination and multicentre evaluation of Xe lung MR imaging.
ADVANCES IN KNOWLEDGE
Our work successfully demonstrates the feasibility of multicentre clinical Xe MRI with a portable hyperpolariser system.
目的
设计并构建一种用于临床可及的氙气-129（Xe）肺部 MRI 的便携式 Xe 极化器。
方法
极化器系统由六个主要功能组件组成：（i）激光二极管阵列和光学器件；（ii）B 线圈组件；（iii）包含光学池的烘箱；（iv）NMR 和光学光谱仪；（v）气体处理歧管；（vi）永磁体中的低温恒温器。所有组件均无需外部设施（如压缩空气或三相电）运行，仅需三个电源插座即可运行。该系统可手动运输到轻便货车中，并可在医院环境中的小面积场地中快速安装。
结果
该极化器可常规提供用于常规临床肺部 MRI 的极化 Xe。为了测试便携性和快速部署的概念，它被运输了 200 公里，在一家以前没有使用过该技术的医院安装，并在系统运输和安装后的第二天获得了具有诊断质量的 Xe MR 图像。
结论
这种便携式 Xe 极化器系统可以成为更广泛的临床传播和 Xe 肺部 MRI 多中心评估的具有成本效益的平台的基础。
知识进展
我们的工作成功地证明了使用便携式极化器系统进行多中心临床 Xe MRI 的可行性。
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