超越静态管道：血管老化的机制和体外模型。
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging.
机构信息
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.
出版信息
Cold Spring Harb Perspect Med. 2022 Jul 21;12(6):a041180. doi: 10.1101/cshperspect.a041180.
The vascular system is a key player for the maintenance of healthy tissues, suggesting how the physiological decline of blood vessel functionality during aging could be a major contributor of organ degeneration. While basic research studies have begun to pinpoint potential mechanisms of vascular aging, it is now critical to translate them into therapeutically relevant options. Microphysiological systems represent a powerful tool to precisely control which combinations of stimuli are provided to in vitro reconstructed blood vessels and to analyze their functional consequences. After highlighting key aspects of vascular aging, this review discusses in vitro models that are able to recapitulate relevant features of blood vessel damage during aging. Strategies to improve current in vitro systems so that they will more faithfully recapitulate vascular aging are proposed, emphasizing the importance of combining in vivo models with microphysiological systems for an effective translation of vascular aging biomarkers and therapies to the clinical level.
血管系统是维持组织健康的关键因素，这表明血管功能随年龄增长而衰退可能是器官退化的主要原因。虽然基础研究已经开始确定血管老化的潜在机制，但现在将其转化为治疗相关的选择至关重要。微生理系统代表了一种强大的工具，可以精确控制向体外重建的血管提供哪些刺激组合，并分析它们的功能后果。在强调血管老化的关键方面之后，本文讨论了能够再现衰老过程中血管损伤相关特征的体外模型。提出了改进现有体外系统的策略，以使它们更真实地再现血管老化，强调将体内模型与微生理系统相结合对于将血管老化生物标志物和治疗方法有效转化到临床水平的重要性。
Zotero 插件