Thomas D F, Fernie D S, Bayston R, Spitz L, Nixon H H
J Pediatr Surg. 1986 Jan;21(1):22-5. doi: 10.1016/s0022-3468(86)80644-3.
Cytopathic toxin neutralized by Clostridium sordellii antiserum was found in the feces of seven out of 13 children with Hirschsprung's disease complicated by enterocolitis (54%). Clostridium difficile was isolated from ten of these 13 children (77%). The frequency of fecal toxin positivity, the magnitude of toxin titers, and the isolation rate of C difficile were all significantly greater in children with Hirschsprung's enterocolitis than in children whose Hirschsprung's disease was not complicated by enterocolitis or in children without Hirschsprung's disease. It is suggested that C difficile may be causally related to enterocolitis in Hirschsprung's disease, but the age distribution of positive results indicates that the major etiologic role is confined to children under three years of age. Vancomycin was found to be an effective form of treatment in the children with enterocolitis in whom it was employed.
在13例患有先天性巨结肠并发小肠结肠炎的儿童中，有7例（54%）的粪便中发现了被索氏梭菌抗血清中和的细胞病变毒素。在这13例儿童中，有10例（77%）分离出艰难梭菌。先天性巨结肠并发小肠结肠炎儿童的粪便毒素阳性频率、毒素滴度大小以及艰难梭菌的分离率，均显著高于未并发小肠结肠炎的先天性巨结肠儿童或无先天性巨结肠的儿童。提示艰难梭菌可能与先天性巨结肠的小肠结肠炎病因相关，但阳性结果的年龄分布表明，主要病因作用局限于3岁以下儿童。在使用万古霉素治疗的小肠结肠炎儿童中，发现它是一种有效的治疗方式。
