Hardy S P, Bayston R, Spitz L
Department of Paediatric Surgery, Institute of Child Health, London.
Arch Dis Child. 1993 Aug;69(2):221-4. doi: 10.1136/adc.69.2.221.
The role of Clostridium difficile in the aetiology of diarrhoea in children with Hirschsprung's disease was investigated in a prospective longitudinal study. In 64 children with Hirschsprung's disease no significant difference was found in the isolation rate of C difficile in patients with diarrhoea (32%) and without diarrhoea (26%). Comparable isolation rates were found in 47 control children with and without diarrhoea (27% and 16% respectively). The number of strains producing toxin B was similar in the four groups of children. In contrast to the disappearance of C difficile by 12 months of age in the control groups of children, C difficile could be repeatedly isolated from a proportion of children with Hirschsprung's disease over 12 months of age. These findings help to reconcile the existing contradictory reports on the incidence of C difficile in Hirschsprung's disease associated enterocolitis.
在一项前瞻性纵向研究中，对艰难梭菌在先天性巨结肠症患儿腹泻病因中的作用进行了调查。在64例先天性巨结肠症患儿中，腹泻患儿（32%）和无腹泻患儿（26%）的艰难梭菌分离率无显著差异。在47例有腹泻和无腹泻的对照儿童中也发现了类似的分离率（分别为27%和16%）。四组儿童中产毒素B菌株的数量相似。与对照组儿童在12个月大时艰难梭菌消失不同，在12个月以上的部分先天性巨结肠症患儿中可反复分离出艰难梭菌。这些发现有助于调和关于先天性巨结肠症相关小肠结肠炎中艰难梭菌发病率的现有矛盾报道。
