Feng Zhangdong, Sun Haitao, Liu Peng, Shi Wei, Han Wei, Ma Lifeng
Department of General Surgery, Beijing Luhe Hospital, Affiliated to Capital Medical University, Beijing, China.
General Surgery (Minimally Invasive Biliary Surgery), The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Transl Cancer Res. 2020 Oct;9(10):6479-6486. doi: 10.21037/tcr-20-2836.
Colorectal cancer (CRC) is a malignant tumor of the digestive tract, with high incidence and mortality. This study aims to investigate the expression of plasma omentin-1 level in patients with CRC and its correlation with the prognosis of patients.
Clinical data of 319 patients (case group) who underwent radical resection of CRC in our hospital from June 2015 to March 2018 were collected, simultaneously, 300 people without the apparent physical disease who underwent physical examination in our hospital during the same period were randomly selected as the control group, plasma omentin-1 levels in the two groups were compared by T-test. Cancer patients were followed up, and multi-factor COX regression analysis was used to analyze the factors affecting patients' recurrence and survival.
The level of plasma omentin-1 in patients with colorectal cancer is closely related to TNM staging and lymph node metastasis. The CRC case group was significantly reduced after surgery, but it was still higher than that in the control group (P<0.05). At the end of the follow-up, 28 cases were lost to follow-up, and 291 cases (91.22%) were effectively followed up. During the follow-up period, the recurrence and metastasis rate was 30.58% (89/291), and the mortality rate was 19.26% (56/291). According to the multi-factor analysis, the risk factors for the recurrence of CRC patients were TNM stage III-IV (OR =1.978, 95% CI: 1.088-3.596), lymph node metastasis (OR =2.073, 95% CI: 1.179-3.645) and omentin-1 level ≥50 ng/mL (OR =3.347, 95% CI: 1.416-7.912). The risk factors for the survival of patients with CRC were poorly differentiated (OR =1.960, 95% CI: 0.985-3.900), lymph node metastasis (OR =2.452, 95% CI: 1.213-4.956), vascular carcinoma thrombus (OR =2.026, 95% CI: 1.036-3.960) and omentin-1 level ≥50 ng/mL (OR =2.067, 95% CI: 1.013-4.218).
The level of plasma omentin-1 is highly expressed in patients with CRC, an independent risk factor for the recurrence and survival of patients.
结直肠癌（CRC）是一种消化道恶性肿瘤，发病率和死亡率都很高。本研究旨在探讨CRC患者血浆网膜素-1水平的表达及其与患者预后的相关性。
收集2015年6月至2018年3月在我院接受CRC根治性切除术的319例患者（病例组）的临床资料，同时随机选取同期在我院进行体检且无明显躯体疾病的300人作为对照组，采用T检验比较两组血浆网膜素-1水平。对癌症患者进行随访，并采用多因素COX回归分析影响患者复发和生存的因素。
结直肠癌患者血浆网膜素-1水平与TNM分期和淋巴结转移密切相关。CRC病例组术后明显降低，但仍高于对照组（P<0.05）。随访结束时，失访28例，有效随访291例（91.22%）。随访期间，复发转移率为30.58%（89/291），死亡率为19.26%（56/291）。多因素分析显示，CRC患者复发的危险因素为TNM分期III-IV期（OR =1.978，95%CI：1.088-3.596）、淋巴结转移（OR =2.073，95%CI：1.179-3.645）和网膜素-1水平≥50 ng/mL（OR =3.347，95%CI：1.416-7.912）。CRC患者生存的危险因素为低分化（OR =1.960，95%CI：0.985-3.900）、淋巴结转移（OR =2.452，95%CI：1.213-4.956）、血管癌栓（OR =2.026，95%CI：1.036-3.960）和网膜素-1水平≥50 ng/mL（OR =2.067，95%CI：1.013-4.218）。
CRC患者血浆网膜素-1水平高表达，是患者复发和生存的独立危险因素。
