Mindel A, Weller I V, Faherty A, Sutherland S, Fiddian A P, Adler M W
Genitourin Med. 1986 Feb;62(1):28-32. doi: 10.1136/sti.62.1.28.
Sixty women patients experiencing a first attack of genital herpes were randomly treated with either oral acyclovir for 42 days or oral acyclovir for five days followed by placebo for 37 days. The median time to the first recurrence in patients receiving acyclovir for 42 days was 66.5 days compared with 24 days in those who received acyclovir for only five days (p less than 0.0001). This significant difference, however, was only observed for the treatment period. The frequency of recurrences was also reduced during the period of treatment in those who received prolonged treatment. During the subsequent follow up period, however, patients in both groups had a similar frequency of recurrences. Patients with infections due to herpes simplex virus type I (HSV I) had a significantly longer time to the first recurrence (p less than 0.001) and fewer recurrences (p less than 0.001) than those infected with HSV II, irrespective of treatment.
60名首次发作生殖器疱疹的女性患者被随机分为两组，一组接受口服阿昔洛韦治疗42天，另一组接受口服阿昔洛韦治疗5天，随后服用安慰剂37天。接受阿昔洛韦治疗42天的患者首次复发的中位时间为66.5天，而仅接受阿昔洛韦治疗5天的患者为24天（p<0.0001）。然而，这种显著差异仅在治疗期间观察到。接受长期治疗的患者在治疗期间复发频率也有所降低。然而，在随后的随访期内，两组患者的复发频率相似。无论接受何种治疗，单纯疱疹病毒I型（HSV I）感染的患者首次复发时间显著更长（p<0.001），复发次数更少（p<0.001），相比感染HSV II的患者。
