局部用阿昔洛韦治疗初发性生殖器疱疹
Topical acyclovir in the treatment of initial genital herpes.
作者信息
Thin R N, Nabarro J M, Parker J D, Fiddian A P
出版信息
Br J Vener Dis. 1983 Apr;59(2):116-9. doi: 10.1136/sti.59.2.116.
In a double-blind randomised placebo-controlled trial of topical acyclovir in initial (first episode) genital herpes 18 patients received acyclovir ointment and 22 matching placebo ointment. Acyclovir significantly reduced the duration of viral shedding from external and all genital lesions, the duration of vesicles, the time to crusting, the time to complete healing of external and all genital lesions, new lesion formation, and the duration of pain, itching, and all symptoms combined for all patients. In female patients alone the time to crusting was not significantly different and the duration of pain only approached significance but the effects were otherwise the same as for all patients. No patients reported any adverse effects of treatment. Topical acyclovir is well tolerated and effective in treating initial genital herpes.
在一项关于局部用阿昔洛韦治疗初发性（首次发作）生殖器疱疹的双盲随机安慰剂对照试验中，18例患者接受阿昔洛韦软膏治疗，22例患者接受匹配的安慰剂软膏治疗。阿昔洛韦显著缩短了所有患者外部及所有生殖器损害的病毒排出持续时间、水疱持续时间、结痂时间、外部及所有生殖器损害完全愈合时间、新损害形成时间以及疼痛、瘙痒和所有症状合并的持续时间。仅在女性患者中，结痂时间无显著差异，疼痛持续时间仅接近显著水平，但其他方面的效果与所有患者相同。没有患者报告治疗的任何不良反应。局部用阿昔洛韦耐受性良好，对治疗初发性生殖器疱疹有效。
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